Protein S/PROS1 Protein, Human (HEK293, His)

Protein S/PROS1 Proteinas are potent antagonists of BMP4 and inhibit BMP4 by binding to BMP4 and preventing receptor interaction. This change redirects neural stem cells from gliogenesis to neurogenesis, thereby promoting the differentiation of neurons in the brain. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Protein S/PROS1 Protein, Human (HEK293, His) is 676 a.a., with molecular weight of 69-89 kDa.

Chordin-like 1 (CHRDL1) protein acts as a potent antagonist of BMP4, exerting its inhibitory function by binding to BMP4 and preventing its interaction with receptors. This interaction results in a pivotal alteration of the fate commitment of neural stem cells, steering them away from gliogenesis towards neurogenesis. In the brain, CHRDL1 contributes to the differentiation of neural stem cells into neurons by impeding the adoption of a glial fate. Beyond its role in neural development, CHRDL1 may play a crucial role in dorsoventral axis formation and embryonic bone development. Additionally, CHRDL1 emerges as a regulator of retinal angiogenesis, modulating BMP4 actions in endothelial cells. Its involvement in anterior segment eye development further underscores the multifaceted role of CHRDL1 in orchestrating key developmental processes.

Human

HEK293

C-His

P07225 (M1-S676)

5627  [NCBI]

69-89 kDa

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.