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Protein S/PROS1 Protein, Human (HEK293, His)

Cat. No.: HY-P74614
COA Handling Instructions

Protein S/PROS1 Proteinas, acting as a potent antagonist of BMP4, inhibits BMP4 by binding to it and preventing receptor interaction. This alteration redirects neural stem cells from gliogenesis to neurogenesis, contributing to neuronal differentiation in the brain. CHRDL1 may play roles in dorsoventral axis formation, embryonic bone development, and retinal angiogenesis. Its involvement in anterior segment eye development highlights the multifaceted role of CHRDL1 in orchestrating key developmental processes. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293, with C-His labeled tag. The total length of Protein S/PROS1 Protein, Human (HEK293, His) is 676 a.a., with molecular weight of 69-89 kDa.

For research use only. We do not sell to patients.

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Description

Protein S/PROS1 Proteinas, acting as a potent antagonist of BMP4, inhibits BMP4 by binding to it and preventing receptor interaction. This alteration redirects neural stem cells from gliogenesis to neurogenesis, contributing to neuronal differentiation in the brain. CHRDL1 may play roles in dorsoventral axis formation, embryonic bone development, and retinal angiogenesis. Its involvement in anterior segment eye development highlights the multifaceted role of CHRDL1 in orchestrating key developmental processes. Protein S/PROS1 Protein, Human (HEK293, His) is the recombinant human-derived protein S/PROS1 protein, expressed by HEK293, with C-His labeled tag. The total length of Protein S/PROS1 Protein, Human (HEK293, His) is 676 a.a., with molecular weight of 69-89 kDa.

Background

Chordin-like 1 (CHRDL1) protein acts as a potent antagonist of BMP4, exerting its inhibitory function by binding to BMP4 and preventing its interaction with receptors. This interaction results in a pivotal alteration of the fate commitment of neural stem cells, steering them away from gliogenesis towards neurogenesis. In the brain, CHRDL1 contributes to the differentiation of neural stem cells into neurons by impeding the adoption of a glial fate. Beyond its role in neural development, CHRDL1 may play a crucial role in dorsoventral axis formation and embryonic bone development. Additionally, CHRDL1 emerges as a regulator of retinal angiogenesis, modulating BMP4 actions in endothelial cells. Its involvement in anterior segment eye development further underscores the multifaceted role of CHRDL1 in orchestrating key developmental processes.

Species

Human

Source

HEK293

Tag

C-His

Accession

P07225 (M1-S676)

Gene ID
Molecular Construction
N-term
PROS1 (M1-S676)
Accession # P07225
His
C-term
Synonyms
Vitamin K-dependent protein S; PROS1; PROS
Molecular Weight

69-89 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

Protein S/PROS1 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Protein S/PROS1 Protein, Human (HEK293, His)
Cat. No.:
HY-P74614
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