PROS1 - protein S Gene

Also Known as PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5627

About PROS1

Cytogenetic location: 3q11.1 Genomic coordinates (GRCh38): 3:93,873,051-93,973,896 (from NCBI)

This gene has 12 transcripts (splice variants), 199 orthologues, 1 paralogue and is associated with 4 phenotypes. Broad expression in liver (RPKM 79.4), heart (RPKM 44.6) and 21 other tissues.

Summary

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

PROS1 Products (2)

mRNA	Protein	Name
NM_000313.4	NP_000304.2	vitamin K-dependent protein S isoform 2 preproprotein
NM_001314077.2	NP_001301006.1	vitamin K-dependent protein S isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	14607961	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PROS1 Protein Structure

Gla

EGF

FXa_inhibition

EGF_CA

Laminin_G_1

Laminin_G_2

0
200
400
600
676 a.a.

Protein Preferred Names	Protein Names
vitamin K-dependent protein S	protein S (alpha)

PROS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	PROS1	P07225	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	PROS1	P07225	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	PROS1	P07225	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	PROS1	P07225	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
Intra	PROS1	P07225	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
Intra	PROS1	P07225	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	PROS1	P07225	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PROS1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74614	Protein S/PROS1 Protein, Human (HEK293, His)	P07225 (N25-S676)	≥ 95%, as determined by reducing SDS-PAGE.

PROS1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83174	Protein S Antibody (YA2919)	WB	Human

Related Diseases

Diseases	Alias
Thrombophilia Due To Protein S Deficiency, Autosomal Recessive	THPH6 Autosomal Recessive Thrombophilia Due To Congenital Protein S Deficiency Severe Hereditary Thrombophilia Due To Congenital Protein S Deficiency Thrombophilia 5 Due To Protein S Deficiency, Autosomal Recessive Autosomal Recessive Thrombophilia Due To Protein S Deficiency
Thrombophilia Due To Protein S Deficiency, Autosomal Dominant	THPH5 Thrombophilia 5 Due To Protein S Deficiency, Autosomal Dominant Autosomal Dominant Thrombophilia Due To Protein S Deficiency Thrombophilia Autosomal Dominant Due To Protein S Deficiency Thrombophilia Autosomal Recessive Due To Protein S Deficiency
Protein S Deficiency	Protein S Deficiency Disease Hereditary Thrombophilia Due To Protein S Deficiency
Thrombophilia	Hypercoagulability State
Prostatitis
Thrombosis	Thrombosis Of Blood Vessel
Purpura Fulminans	Purpura Gangrenosa
Thrombophlebitis	Phlebitis And Thrombophlebitis Of Superficial Vessels Of Lower Extremities Superficial Thrombophlebitis Of Leg Thrombophlebitis Of A Superficial Leg Vein Thrombophlebitis Of Superficial Veins Of Lower Extremity
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1	VKCFD1 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 1 Vitamin K-Dependent Coagulation Defect Multiple Coagulation Factor Deficiency Iii Mcfd3 Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 1 Vkcfd Familial Multiple Coagulation Factor Deficiency Iii Fmfd Iii Factors Ii, Vii, Ix, And X, Combined Deficiency Of Glutamic Acid, Deficient Gamma-Carboxylation Of
Vitamin K Deficiency Bleeding	Vitamin K Deficiency Deficiency Of Vitamin K Vitamin K Vitamin K Deficiency Hemorrhagic Disease
Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors	Hereditary Combined Deficiency Of Factors Ii, Vii, Ix And X Vkcfd
Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 2	VKCFD2 Combined Deficiency Of Vitamin K-Dependent Clotting Factors 2 Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, Type 2
Bile Duct Adenoma	Cholangioadenoma Adenoma Bile Duct Adenoma, Bile Duct
Nail Disorder, Nonsyndromic Congenital, 1	Nonsyndromic Congenital Nail Disorder 1 Twenty-Nail Dystrophy Claw-Shaped Nails Nail Disorder, Nonsyndromic Congenital, 10 Onycholysis NDNC1 Onychauxis, Hyponychia, And Onycholysis Nonsyndromic Congenital Nail Disorder 10 Idiopathic Trachyonychia Twenty Nail Dystrophy Ndnc10 Onychodystrophy Totalis, Isolated Nail Disorder, Nonsyndromic Congenital, 10, Formerly Ndnc10, Formerly Autosomal Dominant Nail Dysplasia Nail Disorder, Nonsyndromic Congenital 1 Onychodystrophy Totalis Sandpaper Nails Trachyonychia Nail Disorder, Non-Syndromic Congenital, 1 Nail Disorder, Non-Syndromic Congenital, 10 Onychauxis Hyponychia And Onycholysis Nail Disorder, Nonsyndromic Congenital, Type 10 Detachment Of Nail Separation Of Nail Plate
Pulmonary Embolism	Pulmonary Artery Embolism Pulmonary Embolus Pulmonary Emboli
Blood Protein Disease	Blood Protein Disorders Blood Protein Disorder
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Meckel Syndrome, Type 7	Meckel Syndrome 7 Nphp3-Related Meckel-Like Syndrome MKS7 Goldston Syndrome Meckel Syndrome Type 7 Meckel-Like Syndrome Type 1 Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst Meckel-Gruber Syndrome, Type 7 Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0918	YO-PRO-1		98.20%	Unkown
HY-110084	BTZO-1		99.32%	Unkown
HY-P4388	Z-Arg-Leu-Arg-Gly-Gly-AMC		99.93%	Unkown
HY-P4388A	Z-Arg-Leu-Arg-Gly-Gly-AMC acetate		99.76%	Unkown
HY-136298A	X77	Inhibitor	99.95%	Unkown
HY-136298	(Rac)-X77	Inhibitor	99.65%	Unkown
HY-RS11202	PROS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18835	Pros1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-149655	D1N8	Inhibitor	/	Unkown
HY-154976	SARS-CoV-2-IN-50	Inhibitor	/	Unkown
HY-174352	TERT ligand-1	Inhibitor	/	Unkown
HY-157145	SARS-CoV-2-IN-69	Inhibitor	/	Unkown
HY-168050	SGC-NSP2PRO-1	Inhibitor	/	Unkown
HY-RS25327	Pros1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PROS1	VGNC	VGNC:102809
Rattus norvegicus	PROS1	RGD	RGD:620971
Canis familiaris	PROS1	VGNC	VGNC:53085
Mus musculus	PROS1	MGD	MGI:1095733
Bos taurus	PROS1	VGNC	VGNC:49565
Macaca mulatta	PROS1	VGNC	VGNC:76426
Others	PROS1	NCBI