1. Apoptosis
  2. Apoptosis
  3. BTZO-1

BTZO-1 

Cat. No.: HY-110084 Purity: 99.57%
Handling Instructions

BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro.

For research use only. We do not sell to patients.

BTZO-1 Chemical Structure

BTZO-1 Chemical Structure

CAS No. : 99420-15-2

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 112 In-stock
Estimated Time of Arrival: December 31
5 mg USD 101 In-stock
Estimated Time of Arrival: December 31
10 mg USD 195 In-stock
Estimated Time of Arrival: December 31
25 mg USD 395 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BTZO-1 binds to Macrophage migration inhibitory factor (MIF) with a Kd value of 68.6 nM, and its binding requires the N-terminal Pro1. BTZO-1 can activate antioxidant response element (ARE)-mediated gene expression and suppress oxidative stress-induced cardiomyocyte apoptosis in vitro[1].

IC50 & Target

Kd:68.6 nM (Macrophage migration inhibitory factor)[1]

In Vitro

BTZO-1 (0-330 nM; 24 hours) dose-dependently suppressed serum deprivation-induced cardiomyocyte death; the minimum effective concentration (MEC1.5), the concentration of a sample necessary to give a 50% increase in cell viability, is 16 nM[1].
BTZO-1 (0.37 μM; 21 hours) upregulates mRNA protein levels of GST Ya and HO-1 in cardiomyocytes[1].

Cell Viability Assay[1]

Cell Line: Primary Neonatal Rat Cardiomyocytes
Concentration: 0-330 nM
Incubation Time: 24 hours
Result: Suppressed serum deprivation or DOX-induced cell death.
Molecular Weight

240.28

Formula

C₁₃H₈N₂OS

CAS No.

99420-15-2

SMILES

O=C1N=C(C2=NC=CC=C2)SC3=CC=CC=C13

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 8.33 mg/mL (34.67 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.1618 mL 20.8091 mL 41.6181 mL
5 mM 0.8324 mL 4.1618 mL 8.3236 mL
10 mM 0.4162 mL 2.0809 mL 4.1618 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BTZO-1BTZO1BTZO 1ApoptosisCardiomyocyteoxidativestressInhibitorinhibitorinhibit

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BTZO-1
Cat. No.:
HY-110084
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