1. Alkaloids
  2. Retrorsine

Retrorsine 

Cat. No.: HY-N6638
Handling Instructions

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes.

For research use only. We do not sell to patients.

Retrorsine Chemical Structure

Retrorsine Chemical Structure

CAS No. : 480-54-6

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Description

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes[1][2].

In Vitro

Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability, depletes GSH, and increases formation of pyrrole-protein adducts[3].

Cell Viability Assay[3]

Cell Line: HSEC-CYP3A4 cells
Concentration: 60 μM, 120 μM , 240 μM
Incubation Time: 24 hours
Result: Significantly decreased cell viability.
In Vivo

Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle[1].

Animal Model: Male Wistar rats (180±20 g), portal branch ligation (PBL) model[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection, twice, separated by 2-week interval
Result: Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL.
Molecular Weight

351.39

Formula

C₁₈H₂₅NO₆

CAS No.

480-54-6

SMILES

O=C(O[[email protected]]1([H])CCN2[[email protected]]1([H])C(COC([[email protected]](CO)(O)[[email protected]](C)C/3)=O)=CC2)C3=C/C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    HCl (pH 2.5) followed by neutralization by NaOH 0.1 N[1]

References
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Keywords:

RetrorsineOthershepatotoxicpyrrolizidinealkaloidPAInhibitorinhibitorinhibit

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