Rituximab (anti-CD20)

Cat. No.: HY-P9913A Pureza: 99.10%: Ficha de datos
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Rituximab (anti-CD20) is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer.

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No. CAS : 174722-31-7

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Based on 12 publication(s) in Google Scholar

Other Forms of Rituximab (anti-CD20):

Rituximab In-stock

12 Publications Citing Use of MCE Rituximab (anti-CD20)

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: Rituximab (anti-CD20) purchased from MedChemExpress. Usage Cited in: Clin Transl Med. 2025 May;15(5):e70336. [Abstract]; DLBCL cells were treated either with ABT-199, ABT-737, or R-CHOP (CHOP plus 10 µg/mL Rituximab) for 48 h.

: Rituximab (anti-CD20) purchased from MedChemExpress. Usage Cited in: Electrophoresis. 2025 Sep 23. [Abstract]; Overlay of CZE electropherograms of rituximab (1 mg/mL) and infliximab analysed using 400 mM eACA, 2 mM TETA, 0.05% HPMC, pH 5.7 (blue), 400 mM GABA, 2 mM TETA, 0.05% HPMC, pH 5.7 (red), 400 mM 7-AHA, 2 mM TETA, 0.05% HPMC, and pH 5.7 (green).

: Rituximab (anti-CD20) purchased from MedChemExpress. Usage Cited in: EBioMedicine. 2024 Nov:109:105379. [Abstract]; Biological activity of ADCC response induced by trastuzumab in BT474 and SKBR3 cells upon treatment with increasing concentrations of rituximab (6 h) was measured.

: Rituximab (anti-CD20) purchased from MedChemExpress. Usage Cited in: Research Square Preprint. 2022 Mar.; In the case of rituximab (17 nM; 48 h) killing, flow cytometry detected the proportion of cells in the G2 phase of each group.

: Rituximab (anti-CD20) purchased from MedChemExpress. Usage Cited in: Cancer Biol Med. 2020 Nov 15;17(4):1026-1038. [Abstract]; Namalwa cells and Daudi cells were mixed with phosphate-buffered saline, rituximab (100 nM), or 161519 TriKE (100 nM) and incubated for 30 min at 37 °C.

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Descripciòn	Rituximab (anti-CD20) is an anti-CD20 chimeric monoclonal antibody used to treat certain autoimmune diseases and types of cancer^[1].
Isotype	Human IgG1 kappa
Recommend Isotype Controls	Human IgG1 kappa, Isotype Control
Species Reactivity	Human
IC₅₀ & Target	CD20/MS4A1
In Vitro	Rituximab (anti-CD20) inhibits the proliferation of stimulated human B cells, which is associated with a relative increase of B cells with an activated naive phenotype. Aside from this population shift, there are no major changes in phenotype or cytokine profile of the various B-cell subsets. B cells stimulated in the presence of rituximab induces stronger T-cell proliferation, compared to B cells stimulated in the absence of rituximab^[1]. All lymphoma cells tested are equally sensitive to antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-mediated phagocytosis of tumor cells, and rituximab-induced apoptosis. Rituximab (anti-CD20) induces high CDC killing of follicular lymphoma cells^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Rituximab (anti-CD20) Related Antibodies
In Vivo	A single injection of rituximab or the murine anti-CD20 Ab 1F5, given i.p. 1 day after the tumor, cures 100% of the animals. Depletion of either NK cells or neutrophils or both in tumor-injected animals does not affect the therapeutic activity of the drug. Similarly, rituximab is able to eradicate tumor cells in athymic nude mice, suggesting that its activity is T cell independent^[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID	931 [NCBI]
Accession	P11836
Application	ELISA, FACS, Functional assay
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular	143.47 kDa
No. CAS	174722-31-7
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Rituximab (anti-CD20)]
Formulation	Please refer to the lot-specific COA for specific buffer information.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Format	Human IgG1 kappa
Biological Activity	Rituximab has a significant ADCC effect on Raji cells in a dose-dependent manner.The EC₅₀ for this effect is 6.56 and 3.25 ng/mL.
Pureza y Documentación	Purity: 99.10% Select Batch: Ficha de datos (261 KB) SDS (251 KB) COA (232 KB) Inhibitory Antibodies User Guide (603 KB)
Referencias	[1]. Kamburova EG, et al. In vitro effects of rituximab on the proliferation, activation and differentiation of human B cells. Am J Transplant. 2012 Feb;12(2):341-50. [Content Brief] [2]. Manches O, et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood. 2003 Feb 1;101(3):949-54. [Content Brief] [3]. Byrd JC, et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis induction. Blood. 2002 Feb 1;99(3):1038-43. [Content Brief]

Rituximab (anti-CD20) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Rituximab (anti-CD20)174722-31-7CD20Inhibitorinhibitorinhibit

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Rituximab (anti-CD20)

Revisión del cliente

Other Forms of Rituximab (anti-CD20):

Rituximab (anti-CD20) Related Antibodies

12 Publications Citing Use of MCE Rituximab (anti-CD20)

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Rituximab (anti-CD20) Related Antibodies

Rituximab (anti-CD20) Related Classifications

Calculadora de molaridad

Calculadora de dilución

The molarity calculator equation

The dilution calculator equation

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Productos vistos recientemente:

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