2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. SC239

SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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SC239

SC239 構造式

CAS 番号 : 1977557-97-3

容量 価格（税別） 在庫状況 数量
1 mg $380 在庫あり
5 mg $950 在庫あり
10 mg $1520 在庫あり
25 mg $3050 在庫あり
50 mg $4900 在庫あり
100 mg   お問い合わせ  
200 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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SC239 関連抗体

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製品説明

SC239 is a cleavable 2-aminophenyl hemiasterlin agent-linker. SC239 can be as the agent-linker for ADC[1]. SC239 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

体外実験

SC239 is composed of a tubulin-targeting 3-aminophenyl hemiasterlin warhead, SC209.html" class="link-product" target="_blank">SC209 (HY-144880), and a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
The SC239 drug-linker is conjugated via a cleavable valine citrulline p-aminobenzyl carbamate linker functionalized with dibenzocyclooctyne (DBCO)[1].
SC239 conjugates exhibits better cytotoxic activity on Igrov1 cells which have lower expression levels of FolRα[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SC239 関連抗体
分子量

1181.42

分子式

C65H84N10O11
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC(C=C4)=CC=C4COC(NC5=CC(C(C)(C)[C@H](NC)C(N[C@@H](C(C)(C)C)C(N(C)[C@@H](C(C)C)/C=C(C)/C(O)=O)=O)=O)=CC=C5)=O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
溶剤 & 溶解度
体外: 

DMSO : 75 mg/mL (63.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8464 mL 4.2322 mL 8.4644 mL
5 mM 0.1693 mL 0.8464 mL 1.6929 mL
10 mM 0.0846 mL 0.4232 mL 0.8464 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

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体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8464 mL 4.2322 mL 8.4644 mL 21.1610 mL
5 mM 0.1693 mL 0.8464 mL 1.6929 mL 4.2322 mL
10 mM 0.0846 mL 0.4232 mL 0.8464 mL 2.1161 mL
15 mM 0.0564 mL 0.2821 mL 0.5643 mL 1.4107 mL
20 mM 0.0423 mL 0.2116 mL 0.4232 mL 1.0580 mL
25 mM 0.0339 mL 0.1693 mL 0.3386 mL 0.8464 mL
30 mM 0.0282 mL 0.1411 mL 0.2821 mL 0.7054 mL
40 mM 0.0212 mL 0.1058 mL 0.2116 mL 0.5290 mL
50 mM 0.0169 mL 0.0846 mL 0.1693 mL 0.4232 mL
60 mM 0.0141 mL 0.0705 mL 0.1411 mL 0.3527 mL
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SC239 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC2391977557-97-3SC 239SC-239Drug-Linker Conjugates for ADCFolate receptor alphaFolRαDBCOADC drug-linkerIgrov1 cellsInhibitorinhibitorinhibit

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製品名:
SC239
製品番号:
HY-148194
数量:
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