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Results for "

146a

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CXCR (1) Fluorescent Dye (1) Interleukin Related (1) MicroRNA (17) NF-κB (1) Tau Protein (1) TNF Receptor (1)
By Research Areas:	Cancer (16) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	miRNA mimics (4) miRNA antagomirs (4) miRNA agomirs (4) MicroRNAs (16) miRNA inhibitors (4)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Recombinant Proteins

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-NP146

Peanut Agglutinin (CY5)	Fluorescent Dye	Others
Peanut Agglutinin CY5 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.). Peanut Agglutinin CY5 is a biological material or organic compound that can be used in life science research .

HY-R00287

*hsa-miR-146a-5p mimic*	MicroRNA	Cancer
hsa-miR-146a-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-146a-5p mimic hsa-miR-146a-5p mimic

HY-RI00287

*hsa-miR-146a-5p inhibitor*	MicroRNA	Cancer
hsa-miR-146a-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-146a-5p inhibitor hsa-miR-146a-5p inhibitor

HY-R00287A

*hsa-miR-146a-5p agomir*	MicroRNA	Cancer
hsa-miR-146a-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-146a-5p agomir hsa-miR-146a-5p agomir

HY-RI00287A

*hsa-miR-146a-5p antagomir*	MicroRNA	Cancer
hsa-miR-146a-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-146a-5p antagomir hsa-miR-146a-5p antagomir

HY-R02681

*mmu-miR-146a-3p mimic*	MicroRNA	Cancer
mmu-miR-146a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-146a-3p mimic mmu-miR-146a-3p mimic

HY-RI02681

*mmu-miR-146a-3p inhibitor*	MicroRNA	Cancer
mmu-miR-146a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-146a-3p inhibitor mmu-miR-146a-3p inhibitor

HY-RI00286A

*hsa-miR-146a-3p antagomir*	MicroRNA	Cancer
hsa-miR-146a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-146a-3p antagomir hsa-miR-146a-3p antagomir

HY-RI00286

*hsa-miR-146a-3p inhibitor*	MicroRNA	Cancer
hsa-miR-146a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-146a-3p inhibitor hsa-miR-146a-3p inhibitor

HY-R00286

*hsa-miR-146a-3p mimic*	MicroRNA	Cancer
hsa-miR-146a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-146a-3p mimic hsa-miR-146a-3p mimic

HY-R04236

*rno-miR-146a-3p mimic*	MicroRNA	Cancer
rno-miR-146a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

rno-miR-146a-3p mimic rno-miR-146a-3p mimic

HY-RI04236

*rno-miR-146a-3p inhibitor*	MicroRNA	Cancer
rno-miR-146a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

rno-miR-146a-3p inhibitor rno-miR-146a-3p inhibitor

HY-R00286A

*hsa-miR-146a-3p agomir*	MicroRNA	Cancer
hsa-miR-146a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-146a-3p agomir hsa-miR-146a-3p agomir

HY-R02681A

*mmu-miR-146a-3p agomir*	MicroRNA	Cancer
mmu-miR-146a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-146a-3p agomir mmu-miR-146a-3p agomir

HY-R04236A

*rno-miR-146a-3p agomir*	MicroRNA	Cancer
rno-miR-146a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-146a-3p agomir rno-miR-146a-3p agomir

HY-120269

CAY10512	NF-κB TNF Receptor Interleukin Related	Neurological Disease Inflammation/Immunology
CAY10512 is a NF-κB inhibitor. CAY10512 can suppress the upregulation of NF-κB-sensitive proinflammatory miRNAs (miRNA-9, miRNA-125b, miRNA-146a, miRNA-155) in cerebrospinal fluid and extracellular fluid. CAY10512 significantly reduces the release of pro-inflammatory cytokines (such as TNF-α, MCP-1, IL-8, IL-6). CAY10512 can be used for researchs on neuroinflammation, islet transplantation and microRNA regulation .

HY-160481

MG-1102	Tau Protein MicroRNA	Neurological Disease
MG-1102 is first-in-class dual binder of monomeric tau and *pre-miRNA-146a. MG-1102 shows specific inhibition of miRNA146a with IC₅₀s of 0.21 mM and 0.36 mM specific inhibition of doublelabeled pre-miRNA146a* and mono-labeled pre-miRNA146a, respectively. MG-1102 interacts with tau monomers with a K_d of 3.21 mM by surface plasmon resonance (SPR). MG-1102 is a potential multi-target-directed ligands (MTDLs) for Alzheimer’s disease (AD) .

HY-RI04236A

*rno-miR-146a-3p antagomir*	MicroRNA	Cancer
rno-miR-146a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

rno-miR-146a-3p antagomir rno-miR-146a-3p antagomir

HY-RI02681A

*mmu-miR-146a-3p antagomir*	MicroRNA	Cancer
mmu-miR-146a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-146a-3p antagomir mmu-miR-146a-3p antagomir

HY-182850

UCUF-965	CXCR	Metabolic Disease
UCUF-965 is a CXCR4 positive allosteric modulator. UCUF-965 potentiates CXCL12-induced β-arrestin recruitment and cAMP signaling, activates lymphoblast migration, induces calcium flux, and does not bind CXCR4’s orthosteric CXCL12 site. UCUF-965 reduces miR-15b and miR-29a levels, increases miR-146a levels in fibroblasts. UCUF-965 enhances angiogenesis and reduces wound healing time in diabetic mice. UCUF-965 can be used for the research of diabetic wound healing impairment .

Cat. No.	Product Name

HY-L146

Metabolic Enzyme Compound Library	4,105 compounds
Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc. MCE designs a unique collection of 4,105 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Metabolic Enzyme Compound Library

4,105 compounds

Metabolism is the set of life-sustaining chemical reactions in organisms that maintain cell homeostasis. Metabolic pathways are enzyme-mediated biochemical reactions that lead to biosynthesis (anabolism) or breakdown (catabolism) of molecules including glucose metabolism, lipid metabolism and amino acid or protein metabolism within a cell or tissue. As catalysts, enzymes are crucial to metabolism as they allow a reaction to proceed more rapidly and tregulate the rate of a metabolic reaction. Due to the importance of metabolic balance in the organism, the abnormal function of metabolic enzymes often leads to the occurrence of a variety of metabolic diseases, such as diabetes, obesity, cardiovascular disease, etc.

MCE designs a unique collection of 4,105 metabolic enzymes related small molecules, which is an important tool for studying the metabolic activities of organisms and developing drugs for metabolic diseases.

Peanut Agglutinin (CY5)	Biochemical Assay Reagents
Peanut Agglutinin CY5 is a plant lectin that can be used as a probe to specifically bind biomolecules (such as polysaccharides, peptides, etc.). Peanut Agglutinin CY5 is a biological material or organic compound that can be used in life science research .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7004

	*FGF basic/bFGF Protein, Human (146a.a)* 35+ Cited Publications rHubFGF; HBGF-2; FGF-2; FGF-b; FGF-basic	Human	E. coli
	FGF-2 is a member of the fibroblast family involved in bone healing, cartilage repair, bone repair, and nerve regeneration. FGF-2 is also a mitotic promoter that accelerates cell proliferation. FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. For example, FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration. FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage, respectively. FGF-2 is also a known carcinogen in GBM, which contributes to glioma growth and vascularization.FGF basic/bFGF Protein, Human (146a.a), consists of 146 amino acids, produced by E.coli with tag free.

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