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18:0 PI

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By Targets:	PI3K (2) Akt (1) AMPK (1) Biochemical Assay Reagents (3) c-Myc (1) Calcium Channel (1) DNA/RNA Synthesis (1) Drug Derivative (1) Endogenous Metabolite (1) Epigenetic Reader Domain (1) Isotope-Labeled Compounds (1) mTOR (1)
By Research Areas:	Cancer (3) Metabolic Disease (7) Neurological Disease (1)
Oligonucleotides:	Phospholipids (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Targets Recommended: PI4K PI5P4K PI3K PI4P5K Glucose-6-Phosphate Isomerase (GPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Endogenous Metabolite	Neurological Disease Cancer
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

HY-NP180

Progesterone/BSA	Calcium Channel	Metabolic Disease
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-W020658S

18:0 PI-d6 DSPI (18:0/18:0)-d₆	Isotope-Labeled Compounds	Metabolic Disease
18:0 PI-d₆ (DSPI(18:0/18:0)-d₆) is the deuterated form of 18:0 PI. 18:0 PI is a membrane-bound signaling molecule that is associated with almost all aspects of cell physiology, including cell growth, metabolism, proliferation, and survival .

HY-175407

18:0-20:4 PI(3,4,5)P3 sodium	Drug Derivative	Others
18:0-20:4 PI(3,4,5)P3 (sodium) is an analogue of phosphatidylinositol. Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC .

HY-N16138

18:0 PI DSPI (18:0/18:0)	Others	Metabolic Disease
18:0 PI is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-N16128

18:0 Lyso PI PI(18:0/0:0)	Others	Metabolic Disease
18:0 Lyso PI is a lysophosphatidylinositol.

HY-157645

18:0-20:4 PI(4)P ammonium	Biochemical Assay Reagents	Others
18:0-20:4 PI(4)P ammonium is a fatty acid.

HY-157648

18:0-20:4 PI(3)P ammonium	Biochemical Assay Reagents	Others
18:0-20:4 PI(3)P ammonium can be obtained by phosphorylation of the inositol ring of phosphatidylinositol and can be used in the preparation of liposomes.

HY-157652

18:0-20:4 PI(3,4,5)P3 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′,5′-trisphosphate ammonium	Biochemical Assay Reagents
18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-164662

mTOR inhibitor-24	mTOR PI3K	Cancer
mTOR inhibitor-24 (comounp 9d) is a mTOR inhibitor, with IC₅₀s of 0.34 nM (mTOR) and 324 nM (PI3K-α) respectively. mTOR inhibitor-24 inhibtis LNCaP cell proliferation (IC₅₀: 180 nM) .

HY-178984

PI3Kα-IN-28	PI3K Epigenetic Reader Domain DNA/RNA Synthesis Akt c-Myc AMPK	Cancer
PI3Kα-IN-28 (Compound 23) is an efficient dual targeted *PI3K/BRD4* inhibitor. PI3Kα-IN-28 can inhibit the proliferation of various cells, such as KYSE180 and KYSE450 cells. PI3Kα-IN-28 can concentration dependently inhibit migration and colony formation, induce G0/G1 phase arrest, significantly inhibit DNA synthesis, and significantly increase the proportion of senescent cells. PI3Kα-IN-28 can inhibit the expression of p-AKT and c-Myc and activate the AMPK-p27 pathway. PI3Kα-IN-28 can be used for research on cancers such as esophageal cancer .

Cat. No.	Product Name

HY-L180

Mitophagy Compound Library	601 compounds
Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms. MCE can provide a library of 601 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Mitophagy Compound Library

601 compounds

Mitochondrial autophagy refers to the selective encapsulation and degradation of damaged mitochondria by cells through the autophagy mechanism, thereby maintaining mitochondrial and cellular homeostasis. The concept of mitochondrial autophagy has received extensive attention since it was proposed. Current studies have shown that the mechanisms of mitochondrial autophagy can generally be divided into two categories: Ubiquitin-dependent pathways and Ub-independent pathways. In addition, mitochondrial autophagy is a research hotspot related to the pathogenesis of neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases and other clinical diseases. Therefore, high-throughput screening based on mitochondrial autophagy can effectively screen out compounds that are closely related to the occurrence of diseases and analyze their mechanisms.

MCE can provide a library of 601 mitophagy compounds, which can be used for drug development and mechanism research in cancer, immunity, infection and other hot research fields.

Cat. No.	Product Name	Type

HY-NP180

Progesterone/BSA	Biochemical Assay Reagents
Progesterone/BSA is a conjugate of Progesterone (HY-N0437) and bovine serum albumin (BSA). Progesterone/BSA cannot penetrate the plasma membrane of human sperm, but still rapidly elevates intracellular free calcium and induces the acrosome reaction. Progesterone/BSA can also act as a probe to specifically bind to progesterone-binding proteins on the membrane of rat brain synaptosomes .

HY-157648

18:0-20:4 PI(3)P ammonium	Biochemical Assay Reagents
18:0-20:4 PI(3)P ammonium can be obtained by phosphorylation of the inositol ring of phosphatidylinositol and can be used in the preparation of liposomes.

HY-157652

18:0-20:4 PI(3,4,5)P3 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′,5′-trisphosphate ammonium	Biochemical Assay Reagents
18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-100355

C18-Ceramide (d18:1/18:0) C18-Ceramide	Structural Classification Alkaloids Neurological Disease Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
C18-Ceramide (d18:1/18:0) is a bioactive molecule with multiple functions in cells, not a traditional agonist or inhibitor targeting a single site. It can act on multiple cellular targets, such as proteins related to endoplasmic reticulum stress (e.g., ATF-4, XBP-1, CHOP), proteins in the PI3K/AKT signaling pathway, and SNARE complex proteins. It exerts activities like inducing cell death, promoting autophagy, and regulating exocytosis through mechanisms such as activating endoplasmic reticulum stress, inhibiting the PI3K/AKT signaling pathway, and affecting lipid raft - related functions. It can be used in research on the mechanism of neuronal injury in the field of neuroscience and in the treatment research of cancers such as glioma in the field of oncology .

Cat. No.	Product Name	Chemical Structure

HY-W020658S

18:0 PI-d6
18:0 PI-d₆ (DSPI(18:0/18:0)-d₆) is the deuterated form of 18:0 PI. 18:0 PI is a membrane-bound signaling molecule that is associated with almost all aspects of cell physiology, including cell growth, metabolism, proliferation, and survival .

Cat. No.	Product Name		Classification

HY-157645

18:0-20:4 PI(4)P ammonium		Phospholipids
18:0-20:4 PI(4)P ammonium is a fatty acid.

HY-157648

18:0-20:4 PI(3)P ammonium		Phospholipids
18:0-20:4 PI(3)P ammonium can be obtained by phosphorylation of the inositol ring of phosphatidylinositol and can be used in the preparation of liposomes.

HY-157652

18:0-20:4 PI(3,4,5)P3 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′,5′-trisphosphate ammonium		Phospholipids
18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-157640

18:0-20:4 PI(5)P diammonium		Phospholipids
18:0-20:4 PI(5)P (diammonium) is a phosphoinositide. Phosphoinositides (PI) are similar to other phospholipids, but the head group is the cyclic myo-inositol.

HY-157643

18:0-20:4 PI (4,5) P2 triammonium		Phospholipids
18:0-20:4 PI (4,5) P2 triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

HY-157649

18:0-20:4 PI (3,5) P2 triammonium		Phospholipids
18:0-20:4 PI (3,5) P2 triammonium is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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18:0 PI

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products