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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
3β-hydroxysteroid dehydrogenase
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "3β-hydroxysteroid dehydrogenase" in MCE Product Catalog:
2
Category:
Human Gut Microbiota Metabolites Immune System Disorder Disease markers Endocrine diseases Endogenous metabolite Disease Research Fields Endocrinology Steroids
Target:
1
1 Cited Publications
Cat. No.: HY-P81196
Synonyms: 3BHS1_HUMAN; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1; beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I; 3-beta-HSD I; 3-beta-hydroxy-5-ene steroid dehydrogenase 1; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase 1; EC:1.1.1.145; 3-beta-hydroxysteroid 3-dehydrogenase 1; EC:1.1.1.270; Delta-5-3-ketosteroid isomerase; Dihydrotestosterone oxidoreductase. EC:1.1.1.210; Steroid Delta-isomerase 1; EC:5.3.3.1; Trophoblast antigen FDO161G; 3BH; HSDB3A;
Cat. No.: HY-105128
CAS No.: 80471-63-2
Synonyms: WIN 32729
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Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC50 of 1.45 nM. Epostane blocks ovulation and pregnancy in rats .
Cat. No.: HY-175592
CAS No.: 3059767-85-7
HEAL-116 is a potent, specific and orally active 3β-hydroxysteroid dehydrogenase type 1 (3βHSD1) inhibitor with an IC50 of 1.18 μM and a KD of 1.32 μM. HEAL-116 inhibits DHEA (HY-14650) metabolism and DHEA-induced target gene expression and cell proliferation. HEAL-116 can be used for cancer research, such as prostate cancer .
Cat. No.: HY-106447
CAS No.: 72141-57-2
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Losulazine is an orally active antihypertensive agent. Losulazine modulates acid phosphatase, 3β-hydroxysteroid dehydrogenase, and 17β-hydroxysteroid dehydrogenase activity. Losulazine can be used for the research of hypertension .
Cat. No.: HY-E71722
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3β-Hydroxysteroid 3-dehydrogenase (EC 1.1.1.270) acts on a variety of 3β-hydroxysteroids.
Cat. No.: HY-113263R
CAS No.: 387-79-1
Synonyms: 17-OHP5 (Standard)
Research Areas:
17a-Hydroxypregnenolone (Standard) is the analytical standard of 17a-Hydroxypregnenolone. This product is intended for research and analytical applications. 17a-Hydroxypregnenolone is a metabolite of Pregnenolone (HY-B0151) and a precursor in the biosynthesis of Dehydroepiandrosterone (HY-14650). 17a-Hydroxypregnenolone is a substrate for the enzyme 3β-hydroxysteroid dehydrogenase (3β-HSD) .
Synonyms: 17-OHP5-d3
Cat. No.: HY-174244
CAS No.: 3082852-63-6
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3βHSD1-IN-1 (Compound 46) is a 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) inhibitor with an IC50 of 55 nM. 3βHSD1-IN-1 can effectively inhibit androgen receptor activity. 3βHSD1-IN-1 can be used in the research of diseases such as prostate cancer .
Cat. No.: HY-113263S1
CAS No.: 2483824-29-7
Synonyms: 17-OHP5-13C2,d2
Cat. No.: HY-E71723
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3β-Hydroxysteroid-4α-carboxylate 3-dehydrogenase (Decarboxylating) (EC 1.1.1.170) catalyses the decarboxylation of the C-4 carbon and the dehydrogenation of a 3β hydroxyl at the C-3 carbon of 3β-hydroxysteroid-4α-carboxylates, and is involved in zymosterol and cholesterol biosynthesis.
Cat. No.: HY-W714186
CAS No.: 60207-93-4
Synonyms: Etaconazole
Etaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD +/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity .
Cat. No.: HY-182447
CAS No.: 69095-83-6
Synonyms: DL111-IT
Research Areas:
Contragestazol (DL111-IT) is a non-hormonal antifertility agent. Contragestazol reduces the expression of Cyclin D1 and CDK4, increases the expression of total retinoblastoma protein (pRb), and decreases the level of hyperphosphorylated pRb. Contragestazol induces G0/G1 phase cell cycle arrest. Contragestazol inhibits embryonic development by inducing luteal cell apoptosis and reducing intrauterine polyamine levels. Contragestazol exhibits antitumor activity against prostate cancer, S180 tumor and H22 tumor. Contragestazol shows extremely potent activity in terminating early pregnancy in animals .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
