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Results for "

Ag(I)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Drug Metabolite (1) Isocitrate Dehydrogenase (IDH) (4) Methionine Adenosyltransferase (MAT) (5) Reactive Oxygen Species (ROS) (2) Reference Standards (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (2) Inflammation/Immunology (3) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15734

AGI-6780 5+ Cited Publications	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-6780 that potently and selectively inhibits the tumor-associated mutant IDH2 ^R140Q with IC₅₀ of 23±1.7 nM. AGI-6780 is less potent against IDH2 ^WT with IC₅₀ of 190±8.1 nM.

HY-112130

AGI-24512 2 Publications Verification	Methionine Adenosyltransferase (MAT)	Cancer
AGI-24512 is a potent methionine adenosyltransferase 2α (MAT2A) inhibitor, with an IC₅₀ of 8 nM. AGI-24512 triggers DNA damage response. AGI-24512 can block proliferation of MTAP-deleted cancer cells in vitro. AGI-24512 can be used for researching anticancer .

HY-18082

AGI-5198 Maximum Cited Publications 20 Publications Verification IDH-C35	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-5198 (IDH-C35) is a potent and selective mutant IDH1 ^R132H inhibitor with an IC₅₀ of 0.07 μM.

HY-14937

Succinobucol 1 Publications Verification AGI-1067; Probucol monosuccinate	Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects.

HY-145777

AGI-43192	Methionine Adenosyltransferase (MAT)	Neurological Disease Cancer
AGI-43192 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that limitedly penetrates the blood-brain barrier. AGI-43192 exhibits inhibitory activitity against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC₅₀s of 32 and 14 nM. AGI-43192 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-43192 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .

HY-145778

AGI-41998	Methionine Adenosyltransferase (MAT)	Neurological Disease Cancer
AGI-41998 is a potent and orally active inhibitor of methionine adenosyltransferase 2A (MAT2A) that effectively penetrates the blood-brain barrier. AGI-41998 exhibits inhibitory activities against MAT2A and S-adenosyl methionine (SAM) in HCT-116 MTAP-null cells with IC₅₀s of 22 nM and 34 nM. AGI-41998 can significantly inhibit the proliferation of HCT-116 cells and tumor growth. AGI-41998 can be used to study the role of SAM regulation in the central nervous system (CNS) and colon cancer .

HY-W009311

Thiomichler's ketone 4,4'-Bis(dimethylamino)thiobenzophenone	Biochemical Assay Reagents	Others
Thiomichler's ketone (4,4'-Bis (dimethylamino) thiobenzophenone) is a heavy metal complexing agent and a colorimetric/spectrophotometric reagent. Thiomichler's ketone shows selectivity for Hg ²⁺ at pH 3, and exhibits activity towards Pd ²⁺ and Ag ⁺ at pH 3.5. Thiomichler's ketone enables accurate detection of trace Pd ²⁺ by forming an extractable Hg ²⁺ complex via micelle-mediated cloud point extraction, or generating a red coordination complex including Pd (TMK)₄. Thiomichler's ketone is applicable for the determination of trace Pd ²⁺ in antibiotics and catalysts of automobile exhaust purifiers .

HY-112129

AGI25696-analog Desmethyl AGI25696	Methionine Adenosyltransferase (MAT)	Cancer
AGI-25696 is a methionine adenosyltransferase 2A (MATA2 ) inhibitors useful for treatment of cancer. AGI-25696 blocks growth of MTAP-deleted tumors in vivo.

HY-121736

AGI-12026 AGI-026	Isocitrate Dehydrogenase (IDH)	Neurological Disease
AGI-12026 is brain-penetrant dual inhibitor of mutant IDH1 and 2. AGI-12026 shows partial inhibition of the IDH1-R132H homodimer as allosteric modulators. AGI-12026 has the potential for research of glioma .

HY-156996

AGI-134	Others	Inflammation/Immunology Cancer
AGI-134 is a fully synthetic alpha-Gal glycolipid. AGI-134 invokes CD8+ T cell-mediated immunity. AGI-134 induces tumor cell destruction and phagocytosis .

HY-120181

AGI-14100	Isocitrate Dehydrogenase (IDH)	Cancer
AGI-14100 is a metabolically stable and orally available mIDH1 inhibitor (IC₅₀=6 nM). The pharmacochemical optimization of AGI-14100 is aimed at eliminating hPXR activation, resulting in the final drug candidate AG-120. AG-120 can be used in the study of cancers carrying IDH1 mutations. The discovery and development of AGI-14100 can be used for further studies of mutant isocitrate dehydrogenase 1 (mIDH1) inhibitors .

HY-162819

Apoptosis inducer 26	Apoptosis	Cancer
Apoptosis inducer 26 (compound [AgCl(dap2SH)(PPh3)2]) is an autophagy inducer based on mononuclear *Ag(I)* ligands, with antibacterial and anticancer activities against a variety of bacterial strains and cancer cell lines. Apoptosis inducer 26 can effectively inhibit the growth of both Gram(+) and Gram(-) bacteria by causing the accumulation of Ag(I) ions in the bacterial periplasm. Apoptosis inducer 26 can intercalate between base pairs of CT DNA and induce apoptosis in A549 cells. Apoptosis inducer 26 also has the ability to scavenge free radicals, which can protect against oxidative stress .

HY-14937R

Succinobucol (Standard) AGI-1067 (Standard); Probucol monosuccinate (Standard)	Reactive Oxygen Species (ROS) Reference Standards	Cardiovascular Disease Inflammation/Immunology Cancer
Succinobucol (Standard) is the analytical standard of Succinobucol. This product is intended for research and analytical applications. Succinobucol is a phenolic antioxidant with anti-inflammatory and antiplatelet effects.

HY-182400

AGI-25696	Methionine Adenosyltransferase (MAT)	Cancer
AGI-25696 is an orally active ethionine adenosyltransferase 2A (MAT2A) inhibitor with an IC₅₀ of 97 nM. AGI-25696 reduces intracellular SAM levels in cancer cells. AGI-25696 inhibits tumor growth in mice bearing subcutaneous KP4 MTAP-null pancreatic xenografts. AGI-25696 can be used for the research of mtap-deleted pancreatic cancer .

HY-165546

AGI-16903	Drug Metabolite	Others
AGI-16903 is a metabolite of Enasidenib (HY-18690). Enasidenib is an orally available, reversible, and selective inhibitor of mutant IDH2 enzymes, with IC₅₀ values of 100 nM and 400 nM against IDH2 ^R140Q and IDH2 ^R172K, respectively .

Cat. No.	Product Name	Type

HY-W009311

Thiomichler's ketone 4,4'-Bis(dimethylamino)thiobenzophenone	Biochemical Assay Reagents
Thiomichler's ketone (4,4'-Bis (dimethylamino) thiobenzophenone) is a heavy metal complexing agent and a colorimetric/spectrophotometric reagent. Thiomichler's ketone shows selectivity for Hg ²⁺ at pH 3, and exhibits activity towards Pd ²⁺ and Ag ⁺ at pH 3.5. Thiomichler's ketone enables accurate detection of trace Pd ²⁺ by forming an extractable Hg ²⁺ complex via micelle-mediated cloud point extraction, or generating a red coordination complex including Pd (TMK)₄. Thiomichler's ketone is applicable for the determination of trace Pd ²⁺ in antibiotics and catalysts of automobile exhaust purifiers .

Thiomichler's ketone

4,4'-Bis(dimethylamino)thiobenzophenone

Biochemical Assay Reagents

Thiomichler's ketone (4,4'-Bis (dimethylamino) thiobenzophenone) is a heavy metal complexing agent and a colorimetric/spectrophotometric reagent. Thiomichler's ketone shows selectivity for Hg ²⁺ at pH 3, and exhibits activity towards Pd ²⁺ and Ag ⁺ at pH 3.5. Thiomichler's ketone enables accurate detection of trace Pd ²⁺ by forming an extractable Hg ²⁺ complex via micelle-mediated cloud point extraction, or generating a red coordination complex including Pd (TMK)₄. Thiomichler's ketone is applicable for the determination of trace Pd ²⁺ in antibiotics and catalysts of automobile exhaust purifiers .

Species:	Virus (4)
Tag:	His (4)
Source:	HEK293 (3) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73939

	*HA1/Hemagglutinin Protein, Influenza B (AGI64446, HEK293, His)* HA; Hemagglutinin; HA/Hemagglutinin, Influenza B (B/Massachusetts/03/2010, HEK293, His)	Virus	HEK293
	The Angiopoietin-1 Protein is a secreted glycoprotein that is a key ligand in the vascular tyrosine kinase signaling pathway. ANGPT1 stimulates angiogenesis by activating PTK2/FAK and downstream kinase MAPK1/ERK2 and MAPK3/ERK1 signaling pathways. ANGPT1 affects the proliferation, migration and differentiation of skeletal muscle cells. HA/Hemagglutinin Protein, Influenza B (AGI64446, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P73967

	*HA/Hemagglutinin Protein, H7N9 (AGI60301, sf9, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H7N9 (A/Hangzhou/1/2013, sf9, His)	Virus	Sf9 insect cells
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H7N9 (AGI60301, sf9, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by Sf9 insect cells , with C-His labeled tag.

HY-P73968

	*HA/Hemagglutinin Protein, H7N9 (AGI60301, HEK293, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H7N9 (A/Hangzhou/1/2013, HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H7N9 (AGI60301, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

HY-P73969

	*HA1/Hemagglutinin Protein, H7N9 (AGI60301, HEK293, His)* HA; Hemagglutinin; HA/Hemagglutinin Protein, H7N9 (A/Hangzhou/1/2013, HA1, HEK293, His)	Virus	HEK293
	The hemagglutinin (HA) protein attaches viral particles to host cells by binding to sialic acid-containing receptors and induces viral particle internalization through clathrin-dependent endocytosis. HA also promotes an alternative clathrin- and caveolin-independent pathway for some virions. HA/Hemagglutinin Protein, H7N9 (AGI60301, HA1, HEK293, His) is the recombinant Virus-derived HA/Hemagglutinin protein, expressed by HEK293 , with C-His labeled tag.

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