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C2 L-Erythro ceramide (d18:1/2:0)

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Autophagy (1) Biochemical Assay Reagents (4) Ceramidase (1) Endogenous Metabolite (1) Fungal (1) Liposome (1) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (3) Infection (1) Metabolic Disease (2) Neurological Disease (2)
Click Chemistry:	Alkynes (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-154831

C22-Ceramide (d18:1/22:0) N-Behenoyl-D-Erythro-sphingosine; C22-ceramide; Cer d18:1/22:0	Liposome	Metabolic Disease
C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

HY-115703

C17 Ceramide (d18:1/17:0) N-Heptadecanoyl-D-Erythro-sphingosine	Biochemical Assay Reagents	Metabolic Disease
C17 Ceramide (d18:1/17:0) (N-Heptadecanoyl-D-erythro-sphingosine) is a phospholipid internal standard. C17 Ceramide (d18:1/17:0) is used in studies of medium-chain acyl-CoA dehydrogenase deficiency (MCADD) .

HY-170035

GlcCer (d18:1/18:0) C18 Glucosyl(β) ceramide (d18:1/18:0); D-glucosyl-β-1,1' N-stearoyl-D-Erythro-sphingosine	Fungal Wnt β-catenin	Infection Neurological Disease Cancer
GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipids that activates the Wnt/β-catenin pathway by targeting LRP6. GlcCer (d18:1/18:0) drives EMT, migration, invasion and GBA1-mediated liver cancer metastasis. GlcCer (d18:1/18:0) accumulates to impair lysosomal function and induce toxic α-synuclein aggregation. GlcCer (d18:1/18:0) supports growth, sporulation, germination and virulence in Penicillium digitatum. GlcCer (d18:1/18:0) is reduced in demyelinated mouse corpus callosum. GlcCer (d18:1/18:0) can be used for the research of liver cancer, synucleinopathies, fungal, Parkinson’s disease and Gaucher disease .

HY-165064

*C2 L-Erythro* ceramide (d18:1/2:0)** L-Erythro cer(d18:1/2:0); N-Acetyl-L-Erythro-sphingosine; Acetyl-L-Erythro-sphingosine	Apoptosis	Cancer
C2 L-Erythro ceramide (d18:1/2:0) is a cell-permeable sphingolipid. C2 L-Erythro ceramide (d18:1/2:0) induces cell cycle arrest in the G0/G1 phase and inhibits cell growth .

HY-139062

C6 Urea Ceramide C6 ceramide (d18:1/6:0) Urea; Cer(d18:1/6:0) Urea; D-Erythro-Urea-C6-ceramide	Apoptosis Ceramidase Autophagy β-catenin	Cancer
C6 Urea Ceramide (Cer(d18:1/6:0) Urea) is an inhibitor of neutral ceramidase. C6 Urea Ceramide increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and HT-29 colon cancer cells. C6 Urea Ceramide (5-10 μM) inhibits proliferation of HT-29 cells and induces apoptosis and autophagy, but is not toxic to non-cancerous cells. C6 Urea Ceramide decreases total and phosphorylated β-catenin levels in HT-29 and HCT116 cells, and induces colocalization of β-catenin with the 20S proteasome. C6 Urea Ceramide (1.25, 2.5, and 5 mg/kg) reduced tumor growth and increased C16, C18, C20, and C24 ceramide levels in tumor tissues in the HT-29 mouse xenograft model.

HY-158873

N,N-Dihexyl sphingosine (d18:1/6:0/6:0) N,N-Dihexyl-D-Erythro-sphingosine	Endogenous Metabolite	Neurological Disease
N,N-Dihexyl sphingosine (d18:1/6:0/6:0) (N,N-Dihexyl-D-erythro-sphingosine) is a synthetic analog of C18-Ceramide (HY-100355).

HY-158878

C12((±)-2'-Hydroxy) dihydro ceramide (d18:0/12:0) (±)-2'-Hydroxy cer(d18:0/12:0); (±)-2'-Hydroxy ceramide (d18:0/12:0); N-(R,S)-α-Hydroxydodecanoyl-D-Erythro-dihydrosphingosine	Biochemical Assay Reagents	Others
C12((±)-2'-Hydroxy) dihydro ceramide (d18:0/12:0) is the 2’-hydroxylated form of C12 dihydro ceramide.

HY-176102

C6 Ceramide (d18:1/6:0) alkyne N-Hexanoyl-D-Erythro-sphingosine alkyne	Biochemical Assay Reagents	Others
C6 Ceramide (d18:1/6:0) alkyne is an ω-alkyne derivative of C6 ceramide. The terminal alkyne group can be used in click chemistry reactions to tag C6 ceramide with fluorescent or biotinylated labels, allowing the analysis of the metabolism and biological activity of C6 ceramide.

HY-165087

C6 Biotin ceramide (d18:1/6:0) N-Hexanoyl-biotin-D-Erythro-sphingosine	Biochemical Assay Reagents	Others
C6 Biotin ceramide (d18:1/6:0) is a biotin-labeled ceramide.

C22-Ceramide (d18:1/22:0) N-Behenoyl-D-Erythro-sphingosine; C22-ceramide; Cer d18:1/22:0	Biochemical Assay Reagents
C22-Ceramide (d18:1/22:0) (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide (d18:1/22:0) reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes .

Cat. No.	Product Name		Classification

HY-176102

C6 Ceramide (d18:1/6:0) alkyne N-Hexanoyl-D-Erythro-sphingosine alkyne		Alkynes
C6 Ceramide (d18:1/6:0) alkyne is an ω-alkyne derivative of C6 ceramide. The terminal alkyne group can be used in click chemistry reactions to tag C6 ceramide with fluorescent or biotinylated labels, allowing the analysis of the metabolism and biological activity of C6 ceramide.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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