C22-Ceramide (d18:1/22:0)
Based on 1 Customer Validation
C22-Ceramide (d18:1/22:0) (N-Behenoyl-D-erythro-sphingosine) is an ultra-long-chain ceramide containing a C22:0 behenoyl acyl chain. C22-Ceramide can be glycosylated via CGT-3 to form C22 glucosylceramide (C22 GlcCer), which in turn maintains clathrin membrane localization and lysosomal homeostasis, inhibits TOR signaling and promotes SKN-1 activation, thereby enhancing oxidative stress resistance and extending the lifespan of C. elegans. C22-Ceramide can be used in research on cardiometabolic diseases such as type 2 diabetes, obesity, dyslipidemia, coronary artery disease and thin-cap fibroatheroma (TCFA), as well as oxidative stress and aging-related studies.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 27888-44-4
- Formula: C40H79NO3
- Molecular Weight:622.06
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-100354
C16-Ceramide (d18:1/16:0) -
HY-100355
C18-Ceramide (d18:1/18:0) -
HY-134508
C24-Ceramide -
HY-134575
C24:1-Ceramide -
HY-112016
C20 Ceramide (d18:1/20:0) -
HY-141582
Ceramide 3 -
HY-134508A
C24-Ceramide (d18:1/24:0) -
HY-141578
C18:1-Ceramide -
HY-113498
Sphingomyelin -
HY-N0830
Palmitic acid -
HY-W590669
C16-Dihydroceramide -
HY-W923646
C24:1-Dihydro-ceramide
Biological Activity
Description
In Vitro
C22-Ceramide (d18:1/22:0) (N-Behenoyl-D-erythro-sphingosine) (10 μM; 3 d) does not significantly inhibit the differentiation of naïve CD4+ T cells from C57BL/6 mice into pathogenic Th17 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 27888-44-4
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Appearance Solid
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Molecular Weight 622.06
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Formula C40H79NO3
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Color White to off-white
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SMILES
CCCCCCCCCCCCCCCCCCCCCC(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)=O
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Synonyms
N-Behenoyl-D-erythro-sphingosine; C22-Ceramide; Cer d18:1/22:0
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
Ethanol : 5 mg/mL (8.04 mM; ultrasonic and warming and heat to 60°C)
DMF : 0.33 mg/mL (0.53 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 1.6076 mL | 8.0378 mL | 16.0756 mL | 40.1890 mL |
| 5 mM | 0.3215 mL | 1.6076 mL | 3.2151 mL | 8.0378 mL |
C22-Ceramide (d18:1/22:0) Related Classifications
HY-154831 Related Classifications
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