GlcCer (d18:1/18:0)
Based on 1 Customer Validation
GlcCer (d18:1/18:0) (C18 Glucosyl(β) ceramide (d18:1/18:0)) is a glycosphingolipids that activates the Wnt/β-catenin pathway by targeting LRP6. GlcCer (d18:1/18:0) drives EMT, migration, invasion and GBA1-mediated liver cancer metastasis. GlcCer (d18:1/18:0) accumulates to impair lysosomal function and induce toxic α-synuclein aggregation. GlcCer (d18:1/18:0) supports growth, sporulation, germination and virulence in Penicillium digitatum. GlcCer (d18:1/18:0) is reduced in demyelinated mouse corpus callosum. GlcCer (d18:1/18:0) can be used for the research of liver cancer, synucleinopathies, fungal, Parkinson’s disease and Gaucher disease.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 95119-86-1
- Formula: C42H81NO8
- Molecular Weight:728.09
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GlcCer (d18:1/18:0) levels are elevated in both whole cells and the plasma membrane of HepG2 cells with stable GBA1 knockdown, representing the most markedly increased GlcCer subspecies in the plasma membrane and forming an endogenous in situ interaction with the Wnt co-receptor LRP6[1].
GlcCer (d18:1/18:0) (4 days) is produced by wild-type Penicillium digitatum, is absent in PdGcs1 deletion mutants, and is reconstituted in PdGcs1 complement mutants, confirming PdGcs1 encodes the glucosylceramide synthase responsible for its biosynthesis[3].
GlcCer (d18:1/18:0) deficiency in PdGcs1-deleted Penicillium digitatum suppresses vegetative growth, sporulation, and conidial germination, and these defects are fully restored in complemented strains[3].
GlcCer (d18:1/18:0) (4 days) is produced by wild-type Penicillium digitatum PdKH8, is absent in PdGcs1 deletion mutants, and is reconstituted in PdGcs1 complement mutants[4].
GlcCer (d18:1/18:0) (5 days (radial growth and sporulation); 8, 12, 16, 24 hours (conidial germination)) is required for normal vegetative growth, sporulation, and conidial germination in Penicillium digitatum, as evidenced by impaired growth, reduced sporulation, and delayed germination in PdGcs1 deletion mutants (which cannot produce GlcCer (d18:1/18:0)) and restoration of these traits in complement mutants[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 95119-86-1
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Appearance Solid
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Molecular Weight 728.09
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Formula C42H81NO8
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Color White to off-white
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SMILES
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCCCC)=O)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO
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Synonyms
C18 Glucosyl(β) ceramide (d18:1/18:0); D-glucosyl-β-1,1' N-stearoyl-D-erythro-sphingosine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 2.5 mg/mL (3.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
[1]. Qiu Z, et al. GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway. Cell Death Dis. 2022;13(5):508. Published 2022 May 30. [Content Brief]
[2]. Lerche S, et al. CSF d18:1 sphingolipid species in Parkinson disease and dementia with Lewy bodies with and without GBA1 variants. NPJ Parkinsons Dis. 2024;10(1):198. Published 2024 Oct 24. [Content Brief]
[3]. Zhu C, et al. Glucosylceramides are required for mycelial growth and full virulence in Penicillium digitatum. Biochem Biophys Res Commun. 2014;455(3-4):165-171. [Content Brief]
[4]. Zhao Z, et al. Untargeted Metabolomic Profiling of Cuprizone-Induced Demyelination in Mouse Corpus Callosum by UPLC-Orbitrap/MS Reveals Potential Metabolic Biomarkers of CNS Demyelination Disorders. Oxid Med Cell Longev. 2021;2021:7093844. Published 2021 Sep 14. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3735 mL | 6.8673 mL | 13.7346 mL | 34.3364 mL |
GlcCer (d18:1/18:0) Related Classifications
HY-170035 Related Classifications
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- GlcCer (d18:1/18:0)
- 95119-86-1
- C18 Glucosyl(β) ceramide (d18:1/18:0)
- D-glucosyl-β-1,1' N-stearoyl-D-erythro-sphingosine
- Fungal
- Wnt
- β-catenin
- epithelial-mesenchymal transition
- HepG2 liver cancer cells
- CNS demyelinating disorders
- glucocerebrosidase
- alpha-synuclein
- LRP6
- Penicillium digitatum
- liver cancer cells
- GBA1
- Wnt/β-catenin signalling pathway
- Inhibitor
- inhibitor
- inhibit