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Results for "

CDK6-IN-2

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

1

Isotope-Labeled Compounds

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-148062
    RSS0680

    		PROTACs CDK AAK1 Cyclin G-associated Kinase (GAK) Salt-inducible Kinase (SIK) LIM Kinase (LIMK) Wee1 SnRK Others
    RSS0680 is a small noncoding RNA (sRNA) targeting the mRNA ribosome binding site (RBS) and a PROTAC with protein kinase degradation activity (Pink: FLT3-IN-17 (HY-148070); Black: Linker (HY-W041970); Blue: E3 ligase Ligand (HY-112078)). RSS0680 competitively binds to RBS through the conserved CCUCCUCCC anti-Shine-Dalgarno (aSD) sequence and inhibits the translation initiation of target genes. RSS0680 can interact with the DUF1127 protein CcaF1, regulate its own stability and participate in bacterial oxidative stress defense, enhancing the host's resistance to heat shock and oxidative damage by affecting pathways such as C1 metabolism and pyruvate dehydrogenase complex. RSS0680 degrades AAK1, CDK1, CDK16, CDK2, CDK4, CDK6, EIF2AK4, GAK, LATSl, LIMK2, MAPK6, MAPKAPK5, MARK2, MARK4, MKNK2, NEK9, RPS6KB1, SIK2, SNRK, STK17A, STK17B, STK35, and WEEl. RSS0680 can be used to study diseases or disorders mediated by aberrant kinase activity and regulatory mechanisms of noncoding RNAs in α-proteobacteria[1][2].
    RSS0680
  • HY-181483
    CDK6-IN-2

    		CDK Reactive Oxygen Species (ROS) Apoptosis Autophagy Caspase Cancer
    CDK6-IN-2 is a CDK6 covalent inhibitor with an IC50 of 0.013 μM. CDK6-IN-2 inhibits the proliferation and migration of triple-negative breast cancer cells, and induces cell cycle arrest and apoptosis. CDK6-IN-2 induces ROS accumulation and mitochondrial damage through cellular metabolic reprogramming. CDK6-IN-2 exhibits anti-tumor activity and can be used for the research of triple-negative breast cancer .
    CDK6-IN-2
  • HY-E70687
    CDK6/CycD2 Recombinant Human Active Protein Kinase

    		CDK Cancer
    CDK6 is a cell-cycle kinases that regulate exit from the G1 phase of the cell cycle. CDK6 is directly involved in transcription in tumor cells and in hematopoietic stem cells. CDK6/CycD2 Recombinant Human Active Protein Kinase is an ortholog of CDK6 .
    CDK6/CycD2 Recombinant Human Active Protein Kinase
  • HY-176174S
    CDK2-IN-46

    		Isotope-Labeled Compounds CDK Cancer
    CDK2-IN-46 (compound 5g) is a selective CDK2 inhibitor with an IC50 of 0.3 nM. CDK2-IN-46 has a selectivity of >200-fold for CDK1, CDK7, CDK9, CDK4, and CDK6. CDK2-IN-46 shows improves rat and cyno pharmacokinetic profiles .
    CDK2-IN-46
  • HY-176718
    VEGFR-2-IN-69

    		Caspase CDK Telomerase VEGFR Cancer
    VEGFR-2-IN-69 (Compound 5A) is a dual inhibitor of VEGFR-2 and Telomerase, which upregulates the expression of caspase 3, caspase 8 and caspase 9, while downregulating CDK-2, CDK-4 and CDK-6. VEGFR-2-IN-69 exhibits an IC50 of 15.46 µM against HCT116 cells .
    VEGFR-2-IN-69
  • HY-180278
    PROTAC CDK6 ligand 2

    		CDK Cancer
    PROTAC CDK6 ligand 2 is a ligand for target CDK6 protein for PROTAC. PROTAC CDK6 ligand 2 can be used for the synthesis of PROTAC CDK6 Degrader 1 (HY-180277) .
    PROTAC CDK6 ligand 2
  • HY-180262
    PROTAC CDK6 Degrader 2

    		PROTACs CDK Cancer
    PROTAC CDK6 Degrader 2 (compound 48b), the active form of PROTAC CDK6 Degrader 1 (HY-180277), is a potent and selective PROTAC CDK6 degrader that binds strongly to KLHDC2 (KD = 0.005 μM). PROTAC CDK6 Degrader 2 functions through a KLHDC2-dependent and ubiquitin-proteasome-mediated mechanism. PROTAC CDK6 Degrader 2 can be used for cancer research .
    PROTAC CDK6 Degrader 2
  • HY-180263
    KLHDC2 ligand 4

    		Ligands for E3 Ligase Cancer
    KLHDC2 ligand 4 (compound KL-3 (8)) is an E3 ligase ligand that can be used for synthesis of PROTAC CDK6 Degrader 2 (HY-180262) .
    KLHDC2 ligand 4
  • HY-180264
    KLHDC2 ligand 4-cyclohexane-CO-pip-cyclobutane

    		E3 Ligase Ligand-Linker Conjugates Cancer
    KLHDC2 ligand 4-cyclohexane-CO-pip-cyclobutane is an E3 ubiquitinase ligand-linker conjugate that can be used for synthesis of PROTAC CDK6 Degrader 2 (HY-180262) .
    KLHDC2 ligand 4-cyclohexane-CO-pip-cyclobutane

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