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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
8 Results for "
CP1
" in MedChemExpress (MCE) Product Catalog:
Products (8)
8 Results for "CP1" in MCE Product Catalog:
2
2 Cited Publications
MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion [1].
1
1 Cited Publications
Cat. No.: HY-P74649
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PCBP1; Nucleic Acid-Binding Protein SUB2.3; Poly(RC) Binding Protein 1; Epididymis Secretory Protein Li 85; Heterogeneous Nuclear Ribonucleoprotein E1; Alpha-CP1; Poly(RC)-Binding Protein 1; HEL-S-85; HnRNP-E1; Heterogenous Nuclear Ribonucleoprotein E1; H
Cat. No.: HY-W187279
CAS No.: 857054-03-6
Target:
Research Areas:
Karrikin 2 is a seed germination stimulant identified in smoke produced by plant combustion. Karrikins induce seed germination in Arabidopsis thaliana, lettuce, E. penduliflora and S. orbiculatum. Karrikin 2 upregulates the expression of gibberellin (GA) biosynthesis genes GA3ox1, GA3ox2 and the gibberellin GA4-responsive gene CP1 in Arabidopsis thaliana seeds [1].
Cat. No.: HY-179055
CAS No.: 3063030-38-3
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PROTAC DAPK1 Degrader-1 (Compound CP1) is a DAPK1 PROTAC degrader with a DC50 of 119.6 nM. PROTAC DAPK1 Degrader-1 significantly increased the MDM2 protein level. PROTAC DAPK1 Degrader-1 significantly reduced the levels of cleaved caspase-3 and cleaved PARP in a cell apoptosis model induced by the neurotoxin ceramide, indicating that it effectively inhibits neuronal apoptosis by degrading DAPK1. PROTAC DAPK1 Degrader-1 can be used to study neurological diseases such as cerebral ischemia and traumatic brain injury (pink: DAPK1 ligand (HY-179071); blue: CRBN ligand (HY-10984); black: linker (HY-40171)) [1].
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BI 653048, a chemical probe, is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM [1]. BI 653048 inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM) . BI 653048 (Compound 103) is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus .
Cat. No.: HY-12946A
CAS No.: 1198784-97-2
Research Areas:
BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM [1]. BI 653048 phosphate inhibits CP1A2, CYP2D6, CYP2C9, CYP2C19 and CYP3A4 isoforms’ activity and reduces affinity for the hERG ion channel (IC50>30 μM) . BI 653048 phosphate is extracted from patent WO2005028501A1 (Compound 103), is also a HCV NS3 protease inhibitor that can reduce viral loads infected with the hepatitis C virus .
Cat. No.: HY-150665S
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
