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Results for "

CTSB

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (2) CCR (1) Cytochrome P450 (1) Filovirus (1) Parasite (1) SARS-CoV (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (3) Infection (2) Inflammation/Immunology (2) Metabolic Disease (2)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

CTSB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CTSB Human Pre-designed siRNA Set A contains three designed siRNAs for CTSB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CTSB Human Pre-designed siRNA Set A CTSB Human Pre-designed siRNA Set A

Ctsb Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ctsb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ctsb Mouse Pre-designed siRNA Set A Ctsb Mouse Pre-designed siRNA Set A

Ctsb Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ctsb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctsb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ctsb Rat Pre-designed siRNA Set A Ctsb Rat Pre-designed siRNA Set A

CTSL/B-IN-1	Cathepsin SARS-CoV	Infection
CTSLCTSB-IN-1 (compound 212-148) is a bispecific inhibitor of host viral spike cleaver proteins *CTSL/CTSB* and TMPRSS2 with IC₅₀s of 2.13/64.07 nM and 1.38 μM, respectively. CTSLCTSB-IN-1 blocks two relevant SARS-CoV-2 viral entry pathways by inhibiting the viral spike cleavage and can be applied to anti-SARS-CoV-2 research .

Ezurpimtrostat GNS561	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat (compound 2-2) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases (extracted from patent WO2020048694 A1) .

Ezurpimtrostat hydrochloride GNS561 hydrochloride	Others	Metabolic Disease Inflammation/Immunology Cancer
Ezurpimtrostat hydrochloride (compound 2-3) is a potent and orally active anti-fibrotic agent. Ezurpimtrostat hydrochloride reduces significantly the liver fibrosis in DEN (diethyl nitrosamine) cirrhotic rat model. Ezurpimtrostat hydrochloride can be used for the research of fibrosis, cancer, autophagy and cathepsins B (CTSB), L (CTSL) and D (CTSD) related diseases .

K777 1 Publications Verification	Cathepsin CCR Cytochrome P450 Parasite SARS-CoV Filovirus	Infection Cancer
K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC₅₀ of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC₅₀ values of 0.68 nM and 0.87 nM, respectively .

Cat. No.	Compare	Product Name	Species	Source

	Cathepsin B Protein, Human (L26V, HEK293, His) CTSB; CPSB; APPS	Human	HEK293
	Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (L26V, HEK293, His) is the recombinant human-derived Cathepsin B protein, expressed by HEK293 , with C-His labeled tag and L26V mutation. The total length of Cathepsin B Protein, Human (L26V, HEK293, His) is 322 a.a., with molecular weight of 10-45 kDa.

	Cathepsin B Protein, Rat (HEK293, His) Cathepsin B; APPS; CTSB; CPSB	Rat	HEK293
	Cathepsin B is a lysosomal cysteine protease that plays a role in intracellular protein catabolism. Cathepsin B mediates JNK signaling pathway to regulate the migration of glioma initiation cells. Cathepsin B is involved in the pathology of chronic inflammatory diseases of the airway and joints, as well as cancer and pancreatitis. Cathepsin B Protein, Rat (HEK293, His) is the recombinant rat-derived Cathepsin B protein, expressed by HEK293 , with C-His labeled tag. The total length of Cathepsin B Protein, Rat (HEK293, His) is 322 a.a., with molecular weight of 35-43 kDa.

	Cathepsin B Protein, Human (His) Cathepsin B; APP Secretase; APPS; Cathepsin B1; CTSB; CPSB	Human	E. coli
	Cathepsin B Protein, a thiol protease, is crucial for intracellular protein degradation, cleaving matrix extracellular phosphoglycoprotein MEPE. It's implicated in solubilizing cross-linked TG/thyroglobulin in the thyroid follicle lumen. Associated with tumor invasion and metastasis, Cathepsin B signifies potential relevance in cancer-related pathways. Cathepsin B Protein, Human (His) is the recombinant human-derived Cathepsin B protein, expressed by E. coli , with C-6*His labeled tag. The total length of Cathepsin B Protein, Human (His) is 322 a.a., with molecular weight of 34 & 38-50 kDa, respectively.

	Cathepsin B Protein, Mouse (HEK293, His) rMuCathepsin B, His; Cathepsin B; CTSB; Cathepsin B1	Mouse	HEK293
	Cathepsin B Protein, Mouse (HEK293, His) is an approximately 32-50 kDa Cathepsin B protein with a His-flag. Cathepsin B is an enzymatic protein belonging to the peptidase C1 family.


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