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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA polymerase-IN-1

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

2

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-159078
    PolQi1

    		DNA/RNA Synthesis Cancer
    PolQi1 is a selective inhibitor targeting the Polθ domain of DNA polymerase. PolQi1 inhibits the Polθ-mediated microhomology end joining (TMEJ/alt-EJ) pathway, reducing insertion/deletion (Indels) and imprecise editing events during DNA repair. PolQi1 can enhance the efficiency and accuracy of homology-directed repair (HDR) or Prime editing, and reduce off-target effects; and in combination with DNA-PK inhibitor AZD-7648 (HY-111783), exert efficient genome editing capabilities with dual pathway regulation. PolQi1 can be mainly used in gene editing research (such as CRISPR-Cas9 or Prime editing system optimization) to improve the precision editing efficiency of difficult-to-edit cells (such as primary hepatocytes and mouse embryos) .
    PolQi1
  • HY-131606B
    Cidofovir diphosphate tritriethylamine

    		Drug Metabolite DNA/RNA Synthesis Infection
    Cidofovir diphosphate tri triethylamine is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate tri triethylamine is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
    Cidofovir diphosphate tritriethylamine
  • HY-134103A
    ddGTP trisodium (100 mM in water)

    2′,3′-DideoxyguanosINe 5′-triphosphate trisodium

    		 DNA/RNA Synthesis Others
    ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium (100 mM in water) is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α .
    ddGTP trisodium (100 mM in water)
  • HY-128917
    DNA31

    		DNA/RNA Synthesis Infection
    DNA31 is a potent RNA polymerase inhibitor .
    DNA31
  • HY-W560689
    DNA polymerase-IN-1

    		DNA/RNA Synthesis Cancer
    DNA polymerase-IN-1 (compound 2d) is a DNA polymerase inhibitor (IC50=20.7 μM) with antiproliferative activity against tumor cells .
    DNA polymerase-IN-1
  • HY-131606
    Cidofovir diphosphate

    		HSV CMV DNA/RNA Synthesis Infection
    Cidofovir diphosphate is an active intracellular metabolite of Cidofovir. Cidofovir diphosphate is a selective inhibitor of viral DNA polymerases with Ki values of 6.6, 0.86 and 1.4 μM for HCMV, HSV-1 and HSV-2 DNA polymerase, respectively .
    Cidofovir diphosphate
  • HY-163015
    RNA polymerase-IN-1

    		DNA/RNA Synthesis Infection
    RNA polymerase-IN-1 (compound 4) is s DNA-dependent RNA polymerase inhibitor. RNA polymerase-IN-1 inhibits CYP isozymes .
    RNA polymerase-IN-1
  • HY-171578
    3′-Amino-2′,3′-dideoxy-CTP

    		Nucleoside Antimetabolite/Analog DNA/RNA Synthesis Others
    3′-Amino-2′,3′-dideoxy-CTP is an analogue of nucleoside triphosphate. 3′-Amino-2′,3′-dideoxy-CTP can selectively inhibit DNA polymerase β .
    3′-Amino-2′,3′-dideoxy-CTP
  • HY-105099R
    Rifalazil (Standard)

    KRM-1648 (Standard); ABI-1648 (Standard)

    		 Antibiotic Reference Standards DNA/RNA Synthesis Bacterial Infection Inflammation/Immunology
    Rifalazil (Standard) is the analytical standard of Rifalazil. This product is intended for research and analytical applications. Rifalazil (KRM-1648; ABI-1648), a rifamycin derivative, inhibits the bacterial DNA-dependent RNA polymerase and kills bacterial cells by blocking off the β-subunit in RNA polymerase[1]. Rifalazil (KRM-1648; ABI-1648) is an antibiotic, exhibits high potency against mycobacteria, gram-positive bacteria, Helicobacter pylori, C. pneumoniae and C. trachomatis with MIC values from 0.00025 to 0.0025 μg/ml[3]. Rifalazil (KRM-1648; ABI-1648) has the potential for the treatment of Chlamydia infection, Clostridium difficile associated diarrhea (CDAD), and tuberculosis (TB)[2].
    Rifalazil (Standard)
  • HY-146365
    HIV-1 inhibitor-30

    		DNA/RNA Synthesis HIV Infection Inflammation/Immunology
    HIV-1 inhibitor-30 (compound 10i) is a potent HIV-1 inhibitor with an EC50 value of 40 nM and an IC50 value of 80 nM for HIV-1 RT DNA polymerase. HIV-1 inhibitor-30 has highly antiretroviral activity against seven non-nucleoside reverse transcriptase inhibitor (NNRTI)-resistant HIV-1 strains (RT-K103N; RT-Y181C; RT-K103N,Y181C; RT-L100I,K103N; RT-Y188L; RT-K103N,G190A; RT-K103N,V108I) with IC50s of 0.04~1.42 μM. HIV-1 inhibitor-30 can be used for researching AIDS .
    HIV-1 inhibitor-30
  • HY-134103B
    ddGTP tetrasodium

    2′,3′-DideoxyguanosINe 5′-triphosphate tetrasodium

    		 DNA/RNA Synthesis Others
    ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) tetrasodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP tetrasodium acts as an inhibitor or a substrate for DNA polymerase α .
    ddGTP tetrasodium

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