ddGTP tetrasodium
ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) tetrasodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP tetrasodium acts as an inhibitor or a substrate for DNA polymerase α.
For research use only. We do not sell to patients.
- Formula: C10H12N5Na4O12P3
- Molecular Weight:579.11
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
ddGTP tetrasodium inhibits the formation of both negative and positive DNA strands[1].
ddGTP tetrasodium inhibits DNA polymerase α activity in the presence of Mn2+ at low concentrations (<1 μM)[2].
ddGTP tetrasodium competitively inhibits the incorporation of [3H]dGTP into the DNA[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 579.11
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Formula C10H12N5Na4O12P3
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SMILES
O=[P](O[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)(O[Na])OC[C@@H]1CC[C@H](N2C(NC(N)=N3)=C(N=C2)C3=O)O1
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Synonyms
2′,3′-Dideoxyguanosine 5′-triphosphate tetrasodium
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Debyser Z, et al. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. J Biol Chem. 1992 Jun 15;267(17):11769-76. [Content Brief]
[2]. Ono K, Nakane H. Utilization of 2',3'-dideoxyguanosine 5'-triphosphate as an inhibitor and substrate for DNA polymerase alpha. Biomed Pharmacother. 1990;44(2):115-21. [Content Brief]
[3]. Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183(2):275-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ddGTP tetrasodium Related Classifications
HY-134103B Related Classifications
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