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Results for "

Exo+1

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112670
    Exo1
    5+ Cited Publications

    		 Arf Family GTPase Others
    Exo1 is a chemical inhibitor of the exocytic pathway.
    Exo1
  • HY-174143
    EXO1-IN-1

    		Apoptosis Cancer
    EXO1-IN-1 is a human exonuclease 1 (EXO1) inhibitor (IC50 = 15.7 μM). EXO1-IN-1 inhibits DNA end resection, promotes the accumulation of DNA double-strand breaks, and triggers S-phase polyamylation. EXO1-IN-1 induces apoptosis (Apoptosis) in BRCA1-deficient breast cancer cells. EXO1-IN-1 suppresses the growth of BRCA1-deficient breast cancer xenografts. EXO1-IN-1 can be used in research related to BRCA1-deficient breast cancer [1].
    EXO1-IN-1
  • HY-177512
    MSC778

    		FLAP Cancer
    MSC778 is an effective and orally active flap endonuclease 1 (FEN1) inhibitor with an IC50 of 3 nM and a KD of 2.9 nM. MSC778 exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively kills BRCA2-deficient cells and potentiates the activity of Niraparib (HY-10619) to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft. MSC778 can be used in the research of colorectal cancer [1].
    MSC778
  • HY-P3187
    exo-β-1,4-Xylosidase, Cellulosimicrobium cellulans sp. 21

    		DNA/RNA Synthesis Others
    Exo-1,4-β-xylosidase is an exonuclease that specifically acts on the β-1,4 glycosidic bonds at the non-reducing ends of xylan and xylooligosaccharides. Exo-1,4-β-xylosidase is Ca 2+-dependent and reversibly binds to metal ions to catalyze the hydrolysis of β-1,4 glycosidic bonds, thereby degrading xylan to produce xylose. Exo-1,4-β-xylosidase can be used in research fields such as lignocellulose bioconversion, bioethanol production, and optimization of xylan saccharification processes [1] .
    exo-β-1,4-Xylosidase, Cellulosimicrobium cellulans sp. 21
  • HY-170845
    MU1409

    		Endonuclease Cancer
    MU1409 is an inhibitor of MRE11 nuclease with an IC50 of 12.1 μM. Additionally, MU1409 also inhibits FEN1 and EXO1, with IC50 values of 24.2 and 176.4 μM, respectively. MU1409 affects DNA repair in cells, preventing the degradation of stalled replication forks in BRCA2-deficient cells, making it a promising candidate for research on BRCA2 mutation-induced cancers [1].
    MU1409
  • HY-175883
    FEN1-IN-8

    		FLAP Cancer
    FEN1-IN-8 (compund 15) is a selective FEN1 inhibitor, with IC50 values of < 100 nM for FEN1 and 100 nM to 1 μM for EXO1, respectively. FEN1-IN-8 can be used for study of colorectal cancer and gastric cancer [1].
    FEN1-IN-8
  • HY-RS27243
    Exo1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Exo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Exo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Exo1 Rat Pre-designed siRNA Set A
    Exo1 Rat Pre-designed siRNA Set A
  • HY-RS04585
    EXO1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    EXO1 Human Pre-designed siRNA Set A contains three designed siRNAs for EXO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    EXO1 Human Pre-designed siRNA Set A
    EXO1 Human Pre-designed siRNA Set A
  • HY-RS20731
    Exo1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Exo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Exo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Exo1 Mouse Pre-designed siRNA Set A
    Exo1 Mouse Pre-designed siRNA Set A
  • HY-162274
    Oxazepine

    		Hedgehog Antibiotic Infection Cancer
    Oxazepine (compound 4a) has antimicrobial viability via binding OMPA/ exo-1,3-beta-glucanase proteins. Oxazepine is a hedgehog signaling inhibitor with antitumor viability [1].
    Oxazepine
  • HY-162273
    Antibacterial agent 189

    		Bacterial Smo Gli Infection Cancer
    Antibacterial agent 189 (compound 3a) is a potent antimicrobial agent. Antibacterial agent 189 offers high binding energy against the target OMPA/exo-1,3-beta-glucanase proteins. Antibacterial agent 189 exhibits the potent antimicrobial activities against E. coli, P. aeruginosa, S. aureus, B. subtilis, C. Albicans and A. flavus. Antibacterial agent 189 shows high binding energy against target SMO and SUFU/GLI-1 proteins [1].
    Antibacterial agent 189
  • HY-180573
    ART5537

    		Arf Family GTPase Cancer
    ART5537 is a selective EXO1 inhibitor with a IC50 of 3.4 nM and a Kd of 6.8 nM. ART5537 exerts cellular homologous recombination (HR) inhibition with EC50 of 7.2 nM in HAP1 parental cells. ART5537 shows >200-fold selectivity over a panel of the wider nuclease superfamily. ART5537 exerts biological effects that are exclusively driven by EXO1 inhibition. ART5537 demonstrates sensitization to ionizing radiation and synergy with Olaparib (HY-10162). ART5537 can be used for research in breast cancer and colorectal adenocarcinoma [1].
    ART5537

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