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Exo1 

Cat. No.: HY-112670 Purity: 99.78%
Handling Instructions

Exo1 is a chemical inhibitor of the exocytic pathway.

For research use only. We do not sell to patients.

Exo1 Chemical Structure

Exo1 Chemical Structure

CAS No. : 75541-83-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 180 In-stock
Estimated Time of Arrival: December 31
100 mg USD 310 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Exo1 is a chemical inhibitor of the exocytic pathway.

In Vitro

Exo1 is a modifier of Golgi ARF1 GTPase activity. Because Exo1 affects a subset of the membrane events that are blocked by BFA, but seems to have a different protein target (and presumably has different side effects), it provides an independent means to interfere with Golgi activity. Exo1 Disrupts Vesicular Traffic from the ER to the Golgi apparatus by disrupting Golgi structures. Exo1 inhibits exocytosis with an IC50 of ~20 μM. Exo1 prevents acquisition of endoglycosidase H resistance by newly synthesized proteins such as VSVGts-GFP, transferrin, and MHC class I[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6595 mL 18.2976 mL 36.5952 mL
5 mM 0.7319 mL 3.6595 mL 7.3190 mL
10 mM 0.3660 mL 1.8298 mL 3.6595 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

273.26

Formula

C₁₅H₁₂FNO₃

CAS No.

75541-83-2

SMILES

O=C(OC)C1=CC=CC=C1NC(C2=CC=C(F)C=C2)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Exo1
Cat. No.:
HY-112670
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Exo1

Cat. No.: HY-112670