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Results for "

FK506 (Standard)

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

3

Natural
Products

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13756R
    Tacrolimus (Standard)

    FK506 (Standard); Fujimycin (Standard); FR900506 (Standard)

    		 Reference Standards Phosphatase FKBP Bacterial Autophagy Antibiotic Infection Inflammation/Immunology Cancer
    Tacrolimus (Standard) is the analytical standard of Tacrolimus. This product is intended for research and analytical applications. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .
    Tacrolimus (Standard)
  • HY-B0199R
    Mycophenolate Mofetil (Standard)

    RS 61443 (Standard); TM-MMF (Standard)

    		 Reference Standards Interleukin Related Cancer
    Mycophenolate Mofetil (Standard) is the analytical standard of Mycophenolate Mofetil. This product is intended for research and analytical applications. Mycophenolate mofetil (RS 61443; TM-MMF) hydrochloride is an orally active antimetabolic immunosuppressant with antiproliferative and anti-inflammatory properties. Mycophenolate mofetil hydrochloride significantly inhibits the production of B, T lymphocytes and the proliferation of smooth muscle cells by selectively blocking the de novo purine synthesis pathway. Mycophenolate mofetil hydrochloride effectively reduces adventitial inflammation, medial necrosis and intimal thickening in rat aortic allografts, and decreases the number of lymphocytes expressing the IL-2 receptor, thereby delaying xenograft rejection. Mycophenolate mofetil hydrochloride shows certain toxicity in a hamster-to-rat limb xenotransplantation model when used in combination with FK506 (HY-13756). Mycophenolate mofetil hydrochloride is widely used in studies related to allograft arteriosclerosis (chronic rejection) .
    Mycophenolate Mofetil (Standard)
  • HY-13557R
    Ascomycin (Standard)

    Immunomycin (Standard); FR-900520 (Standard); FK520 (Standard)

    		 Reference Standards FKBP Parasite Fungal Antibiotic Infection Neurological Disease Inflammation/Immunology
    Ascomycin (Standard) is the analytical standard of Ascomycin. This product is intended for research and analytical applications. Ascomycin (Immunomycin; FR-900520; FK520) is an ethyl analog of Tacrolimus (FK506) with strong immunosuppressant properties. Ascomycin is also a macrocyclic polyketide antibiotic with multiple biological activities such as anti-malarial, anti-fungal and anti-spasmodic. Ascomycin prevents graft rejection and has potential for varying skin ailments research[1][2].
    Ascomycin (Standard)
  • HY-102080R
    SAFit2 (Standard)

    		Reference Standards FKBP Cancer
    SAFit2 (Standard) is the analytical standard of SAFit2 (HY-102080). This product is intended for research and analytical applications. SAFit2, a chemical probe, is a highly potent, highly selective FK506-binding protein 51 (FKBP51) inhibitor with a Ki of 6 nM and also enhances AKT2-AS160 binding .
    SAFit2 (Standard)
  • HY-102079R
    SAFit1 (Standard)

    		Reference Standards FKBP Neurological Disease Metabolic Disease
    SAFit1 (Standard) is the analytical standard of SAFit1 (HY-102079). This product is intended for research and analytical applications. SAFit1 is a FK506 binding protein 51 (FKBP51)-specific inhibitor with a Ki of 4±0.3 nM .
    SAFit1 (Standard)

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