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Results for "

FoxM1

" in MCE Product Catalog:

By Targets:	Antibiotic (1) Apoptosis (1) Bacterial (2) CDK (1) PROTACs (1)
By Research Areas:	Cancer (6) Infection (1)

7

Inhibitors & Agonists

1

Peptides

1

Natural
Products

1

Recombinant Proteins

Cat. No.	Product Name	Target	Research Areas

FOXM1-IN-1	Others	Cancer
FOXM1-IN-1 is a potent *FOXM1* inhibitor with an IC₅₀ value of 2.65 µM. FOXM1-IN-1 shows antiproliferative activity. FOXM1-IN-1 decreases the the expression of FOXM1, PLK1, CDC25B protein.

FDI-6	Others	Cancer
FDI-6 is an inhibitor of *FOXM1. FDI-6 binds directly to FOXM1* protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

Thiostrepton	Bacterial Antibiotic	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits *FOXM1. FOXM1* binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.

RCM-1	Others	Cancer
RCM-1 is a forkhead box M1 (FOXM1) inhibitor with an EC₅₀ of 0.72 μM in U2OS cells. RCM-1 blocks the nuclear localization and increased the proteasomal degradation of *FOXM1. RCM-1 can be used for asthma and other chronic airway diseases research.*

Sepin-1	Others	Cancer
Sepin-1 is a potent separase inhibitor with an IC₅₀ value of 14.8 µM. Sepin-1 inhibits cell proliferation, migration and wound healing. Sepin-1 decreases the expression of FoxM1 protein and mRNA level. Sepin-1 shows anti-tumor activity.

Siomycin A	Bacterial Apoptosis	Cancer
Siomycin A is a thiopeptide antibiotic and is a Forkhead box M1(FOXM1) selective inhibitor without affecting other members of the Forkhead box family. Siomycin A has anti-tumor and promotes *apoptosis*.

YX-2-107	PROTACs CDK	Cancer
YX-2-107 is a PROTAC (IC₅₀= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and *FOXM1* expression in vitro and inhibits the development of Ph⁺ ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph⁺) acute lymphoblastic leukemia (ALL).

Cat. No.	Product Name	Target	Research Area

Thiostrepton	Bacterial Antibiotic	Infection
Thiostrepton is a thiazole antibiotic which selectively inhibits *FOXM1. FOXM1* binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.

Cat. No.	Product Name	Target	Category

Thiostrepton	Bacterial Antibiotic	Antibiotics Structural Classification Other Antibiotics Microorganisms Source classification Infection Disease Research Fields Classification of Application Fields
Thiostrepton is a thiazole antibiotic which selectively inhibits *FOXM1. FOXM1* binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.

Cat. No.	Product Name	Species	Source

FOXM1 Protein, Human (His, SUMO-Myc) FKHL16; Forkhead box M1; Forkhead box protein M1; forkhead like 16; Forkhead-related protein FKHL16; FOX M1; FoxM1; FoxM1_HUMAN; FoxM1B; HFH-11; HFH11; HNF-3/fork-head homolog 11; HNF3; INS1; M phase phosphoprotein 2; M-phase phosphoprotein 2; MPHOSPH2; MPP2; PIG29; TGT3; Transcription factor Trident; Trident; WIN; Winged-helix factor from INS1 cells	Human	E. coli

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