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FDI-6 

Cat. No.: HY-112721
Handling Instructions

FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

For research use only. We do not sell to patients.

FDI-6 Chemical Structure

FDI-6 Chemical Structure

CAS No. : 313380-27-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

FDI-6 is an inhibitor of FOXM1. FDI-6 binds directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation.

IC50 & Target

FOXM1[1]

In Vitro

FDI-6 is characterized in depth and is shown to bind directly to FOXM1 protein, to displace FOXM1 from genomic targets in MCF-7 breast cancer cells, and induce concomitant transcriptional down-regulation. MDA-MB-231 ER-negative breast and PEO-1 ovarian cancer cells are sensitive to FDI-6 in cell viability assays (GI50=21.8 μM and 18.1 μM, respectively) and exhibit comparable down-regulation of CDC25B after a 3 h treatment with FDI-6. The transcription factor FOXM1 regulates a network of proliferation-associated genes critical to mitotic spindle assembly, chromosome segregation, and G2/M transition, with depletion leading to cell cycle arrest. Importantly, aberrant up-regulation of FOXM1 has been shown to be a key driver of cancer progression and has been proposed as an initiating factor of oncogenesis[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2861 mL 11.4304 mL 22.8608 mL
5 mM 0.4572 mL 2.2861 mL 4.5722 mL
10 mM 0.2286 mL 1.1430 mL 2.2861 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

437.43

Formula

C₁₉H₁₁F₄N₃OS₂

CAS No.

313380-27-7

SMILES

O=C(C1=C(N)C2=C(C(F)(F)F)C=C(C3=CC=CS3)N=C2S1)NC4=CC=C(F)C=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
FDI-6
Cat. No.:
HY-112721
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FDI-6

Cat. No.: HY-112721