HEPES

By Targets:	Biochemical Assay Reagents (4) Endogenous Metabolite (1) Isotope-Labeled Compounds (2) PPAR (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (9)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0857

*HEPES* 3 Publications Verification	Biochemical Assay Reagents	Others
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis .

HY-108535

HEPES sodium 3 Publications Verification	Biochemical Assay Reagents	Others
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis .

HY-D0857S

HEPES-d18	Isotope-Labeled Compounds	Others
HEPES-d₁₈ is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].

HY-115421A

11-HEPE

Others Metabolic Disease

11-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .
HY-115421

11(R)-HEPE

Others Metabolic Disease

11(R)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .

11-HEPE	Others	Metabolic Disease
11-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .

11(R)-HEPE	Others	Metabolic Disease
11(R)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .

HY-130319A

9-HEPE	PPAR	Cardiovascular Disease Metabolic Disease
9-HEPE, a oxidation product of Eicosapentaenoic acid, is a racemic mixture of 9(R)-HEPE and 9(S)-HEPE. 9-HEPE induces fatty acid oxidation, adipogenesis, and glucose uptake via activation of PPARs in vivo .

HY-126108

(±)8-HEPE	Others	Metabolic Disease
(±)8-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of (±)8-HEPE and 8(R)-HEPE. The ability of (±)8-HEPE to induce hatching of E. modestus and B. balanoides eggs is probably due to the presence of the 8(R) isomer within the racemic mixture.

HY-N7801

(±)5-HEPE	Others	Metabolic Disease
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.

HY-117044A

(±)12-HEPE	Others	Metabolic Disease
(±)12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of (±)12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC₅₀ values of 24 and 25 μM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC₅₀s=8.6-8.8 μM).

HY-130675A

15(S)-HEPE 15(S)-hydroxy-Eicosapentaenoic acid; 15(S)-hydroxy EPA	Others	Inflammation/Immunology
15(S)-HEPE is a monohydroxy fatty acid. 15(S)-HEPE is biosynthesized from eicosapentaenoic acid by 15-lipoxygenase (15-LO). Serum levels of 15(S)-HEPE are elevated in patients with asthma.

HY-130675AS

15(S)-HEPE-d5

Isotope-Labeled Compounds Others

15(S)-HEPE-d₅ is the deuterium labeled 15(S)-HEPE[1].

*15(S)-HEPE-d5*	Isotope-Labeled Compounds	Others
15(S)-HEPE-d₅ is the deuterium labeled 15(S)-HEPE[1].

HY-121888

20-HEPE	Others	Metabolic Disease
20-HEPE is a metabolite of eicosapentaenoic acid formed by ω-oxidation of EPA by cytochrome P450 (CYP) ω-oxidases, including human CYP4F3B. At 10 μM, it activates peroxisome proliferator-activated receptor α (PPARα) in COS-7 cells expressing a luciferase reporter gene. 20-HEPE also activates mouse transient receptor potential vanilloid receptor 1 (mTRPV1) in vitro but lacks analgesic activity in rats.

HY-W747548

12(S)-HEPE	Others	Inflammation/Immunology
12(S)-HEPE is a monohydroxy fatty acid synthesized from EPA by the action of 12-LO. Unstimulated neutrophils metabolize 12(S)-HEPE to 12(S),20-diHEPE, whereas stimulated neutrophils produce 5(S),12(S)-HEPE via the 5-lipoxygenase pathway. The competitive action of 12(S)-HEPE with arachidonic acid as a substrate for 5-LO in the formation of leukotrienes may provide a basis for the anti-inflammatory potential of ω-3 fatty acids.

HY-130319

9(S)-HEPE

Others Metabolic Disease

9(S)-HEPE, a hydroxy fatty acid, is a metabolite of Eicosapentaenoic acid .

9(S)-HEPE	Others	Metabolic Disease
9(S)-HEPE, a hydroxy fatty acid, is a metabolite of Eicosapentaenoic acid .

HY-117044

12(R)-HEPE	Endogenous Metabolite	Metabolic Disease
12(R)-HEPE is a monohydroxy fatty acid synthesized from EPA by the eggs of the sea urchin, S. purpuratus.1 The biological activity of 12(R)-HEPE has not been extensively documented, but may be similar to that of 12(R)-HETE.

HY-115421B

11(S)-HEPE

Others Others

11(S)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .

11(S)-HEPE	Others	Others
11(S)-HEPE is a monohydroxy fatty acid derived from EPA (eicosapentaenoic acid) .

HY-113513

5-HEPE	Others	Cancer
5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

HY-126108A

8(S)-HEPE	Others	Inflammation/Immunology
8(S)-HEPE is a monohydroxy fatty acid produced by lipoxygenase oxidation of EPA. It acts to promote hatching of barnacle eggs at 10 nM, although it is not clearly identified as the natural egg hatching factor.

HY-108665

AR-C66096 tetrasodium FPL 66096 tetrasodium; PSFM-ATP tetrasodium	Biochemical Assay Reagents	Cardiovascular Disease
AR-C66096 tetrasodium is a selective platelet P2Y_T receptor antagonist. AR-C66096 tetrasodium effectively blocks ADP-induced platelet aggregation. AR-C66096 tetrasodium can be used in the research of thromboembolism .

HY-D0856

Bis-Tris	Biochemical Assay Reagents	Others
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

Cat. No.	Product Name	Type

HY-D0857

*HEPES* 3 Publications Verification	Biochemical Assay Reagents
HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis .

HY-108535

HEPES sodium 3 Publications Verification	Biochemical Assay Reagents
HEPES sodium, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES sodium is effective at pH 6.8 to 8.2. HEPES sodium is also a potent inducer of lysosome biogenesis .

HY-D0856

Bis-Tris	Buffer Reagents
Bis-Tris is an amine buffer suitable for protein and nucleic acid systems with a pH buffer range of 5.8-7.2. Bis-Tris can also be mixed with HEPES and cacodylic acid buffer to create a pH 8 environment and monitor fluorescence emission intensity at 305 nm. Gels formulated with Bis-Tris also avoid protein degradation in samples prepared at higher pH (pH 8.5) .

Cat. No.	Product Name

HY-K1034

Tris-HEPES-SDS Powder (500 mL of 1×)

MCE Tris-HEPES-SDS Powder (500 mL of 1×) consists of Tris, HEPES, EDTA and SDS, and is widely used in protein electrophoresis.

*Tris-HEPES-SDS Powder (500 mL of 1×)*
MCE Tris-HEPES-SDS Powder (500 mL of 1×) consists of Tris, HEPES, EDTA and SDS, and is widely used in protein electrophoresis.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113513

5-HEPE	Microorganisms Source classification	Others
5(S)-HEPE is an active metabolite of eicosapentaenoic acid. It is formed from EPA by 5-lipoxygenase (5-LO). 5(S)-HEPE is an agonist of G protein-coupled receptor 119 (GPR119). It increases cAMP accumulation in CHO-K1 cells expressing human GPR119 when used at a concentration of 10 μM. 5(S)-HEPE increases glucose-induced insulin secretion from MING6 insulinoma pancreatic islets and glucagon-like peptide 1 (GLP-1) secretion from HuTu 80 adenocarcinoma cells when used at a concentration of 10 μM. Serum levels of 5(S)-HEPE are elevated in patients with hyperlipidemia.

Cat. No.	Product Name	Chemical Structure

HY-D0857S

HEPES-d18
HEPES-d₁₈ is the deuterium labeled HEPES[1]. HEPES, a nonvolatile zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is also a potent inducer of lysosome biogenesis[2][3][4].

HY-130675AS

15(S)-HEPE-d5

15(S)-HEPE-d₅ is the deuterium labeled 15(S)-HEPE[1].

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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HEPES

Inhibitors & Agonists

Biochemical Assay Reagents

MCE Kits

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Isotope-Labeled Compounds

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