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I kappa B kinase

" in MedChemExpress (MCE) Product Catalog:

標的別:	IKK (1) NF-κB (2) Acyltransferase (1) Drug Derivative (1) Fatty Acid Synthase (FASN) (1) Keap1-Nrf2 (1) PDGFR (1) PPAR (1)
研究分野別:	Cancer (1) Cardiovascular Disease (1) Inflammation/Immunology (3) Metabolic Disease (1)

阻害剤およびアゴニスト

阻害性抗体

天然物

組換えタンパク質

抗体

Targets Recommended: IKK NF-κB

製品番号	製品名	Target	研究分野	構造式

HY-139833

Anti-inflammatory agent 6	NF-κB IKK	Inflammation/Immunology
Anti-inflammatory agent 6 blocks the phosphorylation of *I kappa* b kinase α/β (IKKα/β), IκBα, and nuclear factor kB p65 (NF-κB p65)** which is a key controller of inflammation, thereby showing anti-inflammatory potential.

HY-P992326

BOT1711	PDGFR	Inflammation/Immunology Cancer
BOT1711 is a human IgG1κ monoclonal antibody targeting *PDGFRB/CD140b. PDGFRB/CD140b belongs to type I receptor tyrosine kinases* (RTKs), and is mainly expressed in vascular smooth muscle cells, pericytes, fibroblasts, certain mesenchymal stem cells, and tumor stromal cells.

HY-N18066

Esculeogenin A	Drug Derivative Acyltransferase NF-κB PPAR Fatty Acid Synthase (FASN) Keap1-Nrf2	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, ACAT1/ACAT2 to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia .

製品番号	製品名	Target	研究分野	Image

HY-P992326

BOT1711	PDGFR	Inflammation/Immunology Cancer
BOT1711 is a human IgG1κ monoclonal antibody targeting *PDGFRB/CD140b. PDGFRB/CD140b belongs to type I receptor tyrosine kinases* (RTKs), and is mainly expressed in vascular smooth muscle cells, pericytes, fibroblasts, certain mesenchymal stem cells, and tumor stromal cells.

製品番号	製品名	Category	Target	構造式

HY-N18066

Esculeogenin A	Structural Classification Solanum lycopersicum L. Solanaceae Plants Steroids Source Classification	Drug Derivative Acyltransferase NF-κB PPAR Fatty Acid Synthase (FASN) Keap1-Nrf2
Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, ACAT1/ACAT2 to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia .

Species:	Human (3)
Tag:	His (1) GST (3)
Source:	Sf9 insect cells (3)

製品番号	Compare	製品名	Species	Source	Image

HY-P701788

	IKKε Protein, Human (Active, sf9, GST) IKKε; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	Human	Sf9 insect cells
	IKKε protein is a serine/threonine kinase that coordinates the inflammatory response to viral infection by activating type I IFN, NF-kappa-B, and STAT signaling pathways. Upon activation of the viral RNA sensor, IKKε binds to DDX3X and phosphorylates IRF3, IRF7, and DDX3X, resulting in IRF3 nuclear translocation. IKKε Protein, Human (sf9, GST) is the recombinant human-derived IKKε protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P701786

	IKKβ Protein, Human (sf9, GST) 1 Publications Verification IKBKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB	Human	Sf9 insect cells
	IKKβ protein is a serine kinase that is critical in the NF-kappa-B signaling pathway and can respond to various stimuli such as cytokines or cellular stress. As part of the classical IKK complex, IKKβ activates NF-kappa-B through phosphorylation inhibitors, leading to its degradation and release of NF-kappa-B for gene transcription. IKKβ Protein, Human (sf9, GST) is the recombinant human-derived IKKβ protein, expressed by sf9 insect cells , with N-GST labeled tag.

HY-P706059

	IKBKB Protein, Human (Active, sf9, His-GST) Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B kinase 2; IKK-2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB; 2.7.11.1; IKKB	Human	Sf9 insect cells

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Host:	Mouse (5) Rabbit (9)
Reactivity:	Human (14) Rat (6) Mouse (7)
Application:	IHC-P (5) ICC/IF (9) IF-Tissue (1) IP (5) IHC-F (1) WB (14) FC (3) ELISA (5)
Isotype:	IgG (9) IgG1 (3)
Conjugation:	Non-conjugated (14)
Clonality:	Monoclonal (12) Recombinant (6)
Modification:	Unmodified (12)

製品番号	Compare	製品名	Application	Reactivity	Image

HY-P86384

	IKK alpha Antibody (YA6076) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IKK alpha Antibody (YA6076) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha.

HY-P85216

	IKK alpha Antibody (YA4908) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, FC, ELISA	Human
	IKK alpha Antibody (YA4908) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK alpha.

HY-P82126

	IKK alpha/beta Antibody (YA1871) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, ICC/IF, IP	Human, Mouse, Rat
	IKK alpha/beta Antibody (YA1871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha/beta.

HY-P86459

	IKK alpha/beta Antibody (YA6151) CHUK; IKKA; TCF16; Inhibitor of nuclear factor kappa-B kinase subunit alpha; I-kappa-B kinase alpha; IKK-A; IKK-alpha; IkBKA; IkappaB kinase; Conserved helix-loop-helix ubiquitous kinase; I-kappa-B kinase 1; IKK1; Nuclear factor NF-kappa-B	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	IKK alpha/beta Antibody (YA6151) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha/beta.

HY-P80719

	IKK beta Antibody (YA347) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody (YA347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK beta.

HY-P85217

	IKK beta Antibody (YA4909) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB	Human
	IKK beta Antibody (YA4909) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P87500

	IKK beta Antibody (YA7184) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ELISA	Human
	IKK beta Antibody (YA7184) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P80719A

	IKK beta Antibody (YA347)(PBS only) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody (YA347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK beta.

HY-P87500A

	IKK beta Antibody (YA7184)(PBS only) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ELISA	Human
	IKK beta Antibody (YA7184) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P81866

	IKK epsilon Antibody (YA1611) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, IHC-P, ICC/IF, FC	Human
	IKK epsilon Antibody (YA1611) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK epsilon.

HY-P85218

	IKK epsilon Antibody (YA4910) IKBKE; IKKE; IKKI; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i	WB, IHC-P, IHC-F, IF-Tissue	Human
	IKK epsilon Antibody (YA4910) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to IKK epsilon.

HY-P85530

	IKK beta Antibody (YA5222) I kappa B kinase 2; I kappa B kinase beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK 2; IKK B; IKK beta; IKK-B; IKK-beta; IKK2; IKKB; IKKB_HUMAN; IMD15; Inhibitor of kappa light chain gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta; Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta; Inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa B kinase subunit beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF kappa B inhibitor kinase beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.	WB	Human, Rat
	IKK beta Antibody (YA5222) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P80414

	IKK alpha + IKK beta Antibody (YA349)	WB, ICC/IF, IP	Human, Mouse
	IKK alpha + IKK beta Antibody (YA349) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha + IKK beta.

HY-P80413

	IKK alpha Antibody (YA348)	WB, ICC/IF, IHC-P, FC, IP	Human, Mouse
	IKK alpha Antibody (YA348) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK alpha.

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