NPC1

By Targets:	11β-HSD (1) Autophagy (8) Drug Metabolite (1) Fatty Acid Synthase (FASN) (1) Filovirus (1) Isotope-Labeled Compounds (1) Keap1-Nrf2 (7) PD-1/PD-L1 (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (10) Cardiovascular Disease (8) Infection (1) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W395779

EBOV-IN-1	Filovirus	Infection
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM ^[1].

HY-113845

(+)-Intermedine

Others Neurological Disease

(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

(+)-Intermedine	Others	Neurological Disease
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-RS09474

NPC1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPC1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPC1 Human Pre-designed siRNA Set A NPC1 Human Pre-designed siRNA Set A

HY-RS09475

NPC1L1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
NPC1L1 Human Pre-designed siRNA Set A contains three designed siRNAs for NPC1L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

NPC1L1 Human Pre-designed siRNA Set A NPC1L1 Human Pre-designed siRNA Set A

HY-113845R

(+)-Intermedine (Standard)	Others	Neurological Disease
(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-17376

Ezetimibe 5+ Cited Publications SCH 58235	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S

Ezetimibe-d4 SCH 58235-d₄	Autophagy Keap1-Nrf2 Isotope-Labeled Compounds	Cardiovascular Disease Cancer
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17640

Nicodicosapent	Fatty Acid Synthase (FASN) Autophagy	Metabolic Disease
Nicodicosapent is a fatty acid niacin conjugate that is also an inhibitor of the sterol regulatory element binding protein (SREBP), a key regulator of cholesterol metabolism proteins such as PCSK9, HMG-CoA reductase, ATP citrate lyase, and NPC1L1.

HY-135388

ent-Ezetimibe ent-SCH 58235	Drug Metabolite	Cardiovascular Disease
ent-Ezetimibe (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator ^[1].

HY-136059

Desfluoro-ezetimibe	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator ^[1] .

HY-17376S1

Ezetimibe-d4-1 SCH 58235-d₄-1	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-133114

Ezetimibe ketone EZM-K	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe ketone (EZM-K) is a phase-I metabolite of Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. Ezetimibe is a potent cholesterol absorption inhibitor ^[1] .

HY-17376R

Ezetimibe (Standard) 5+ Cited Publications SCH 58235 (Standard)	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe (Standard) is the analytical standard of Ezetimibe. This product is intended for research and analytical applications. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-P99544

Tagitanlimab HBM-9167; KL-A167	PD-1/PD-L1	Cancer
Tagitanlimab (HBM-9167) is a *humanized anti-PD-L1 antibody* (IgG1κ type). Tagitanlimab selectively blocks the interaction of *PD-L1* and *PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC)* .

HY-17376S1R

Ezetimibe-d4-1 (Standard) SCH 58235-d4-1 (Standard)	Keap1-Nrf2 Autophagy	Cardiovascular Disease Cancer
Ezetimibe-d4-1 (Standard) is the analytical standard of Ezetimibe-d4-1. This product is intended for research and analytical applications. Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-157161

11β-HSD2-IN-1	11β-HSD	Cancer
11β-HSD2-IN-1 (compound CDSN) is a potent inhibitor of 11β-HSD2, inhibiting the metabolism of Cholestane-3β,5α,6β-triol (CT) in cells by 11β-HSD2 into the tumor promoter, carcinosterone. 11β-HSD2-IN-1 inhibits testosterone biosynthesis, thereby inhibiting MCF-7 cell proliferation. 11β-HSD2-IN-1 has immune activity and antiviral infection effects ^[1].

Cat. No.	Product Name	Target	Research Area

HY-P99362

Ensituximab Anti-MUC5AC Reference Antibody (ensituximab); NEO-102	Inhibitory Antibodies	Cancer
Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer ^[1] .

HY-P99544

Tagitanlimab HBM-9167; KL-A167	PD-1/PD-L1	Cancer
Tagitanlimab (HBM-9167) is a *humanized anti-PD-L1 antibody* (IgG1κ type). Tagitanlimab selectively blocks the interaction of *PD-L1* and *PD-1. Tagitanlimab has the potential to be studied in recurrent or metastatic nasopharyngeal carcinoma (NPC)* .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113845

(+)-Intermedine	Alkaloids Pyrrole Alkaloids Source classification Plants Symphytum officinale L. Boraginaceae	Others
(+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

HY-113845R

(+)-Intermedine (Standard)	Structural Classification Alkaloids Source classification Symphytum officinale L. Plants Boraginaceae	Others
(+)-Intermedine (Standard) is the analytical standard of (+)-Intermedine. This product is intended for research and analytical applications. (+)-Intermedine, a pyrrolizidine alkaloid (PA), exhibits significant cytotoxicity in neural progenitor cells (NPCs) .

Cat. No.	Compare	Product Name	Species	Source

HY-P74695

	*Niemann Pick C1/NPC1* Protein, Human (His)** NPC intracellular cholesterol transporter 1; Niemann-Pick C1 protein; NPC1	Human	HEK293
	The Niemann Pick C1/NPC1 protein is an intracellular cholesterol transporter that cooperates with NPC2 to promote cholesterol efflux from the endosomal/lysosomal compartment. NPC2 transfers unesterified cholesterol to the N-terminal domain of NPC1, where the cholesterol is bound in a hydrophobic pocket. Niemann Pick C1/NPC1 Protein, Human (His-Flag) is the recombinant human-derived Niemann Pick C1/NPC1 protein, expressed by HEK293 , with N-His labeled tag. The total length of Niemann Pick C1/NPC1 Protein, Human (His-Flag) is 251 a.a., with molecular weight of ~38-55 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-17376S

Ezetimibe-d4

Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Ezetimibe-d4
Ezetimibe-d₄ is the deuterium labeled Ezetimibe. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

HY-17376S1

Ezetimibe-d4-1
Ezetimibe-d₄-1 is deuterium labeled Ezetimibe. Ezetimibe (SCH 58235) is a potent cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

Cat. No.	Product Name	Application	Reactivity

HY-P82545

Niemann Pick C1 Antibody (YA2290)

Niemann Pick C1 protein precursor; NPC; NPC1
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P81911

Niemann Pick C1 Like 1 Antibody (YA1656)

NPC1 LIKE 1; NPC1L1
WB Human

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