1. NF-κB
    Autophagy
  2. Keap1-Nrf2
    Autophagy
  3. Desfluoro-ezetimibe

Desfluoro-ezetimibe 

Cat. No.: HY-136059
Handling Instructions

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.

For research use only. We do not sell to patients.

Desfluoro-ezetimibe Chemical Structure

Desfluoro-ezetimibe Chemical Structure

CAS No. : 302781-98-2

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Description

Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2].

In Vitro

During the synthetic process development studies of Ezetimibe, an impurity was detected in the final product at levels ranging from 0.05% to 0.15% in reverse phase gradient high performance liquid chromatography (HPLC) method and its molecular weight is determined by LC–MS analysis. The impurity is Desfluoro-ezetimibe[1].

Molecular Weight

391.43

Formula

C₂₄H₂₂FNO₃

CAS No.

302781-98-2

SMILES

O=C1N(C2=CC=CC=C2)[[email protected]](C3=CC=C(O)C=C3)[[email protected]]1CC[[email protected]@H](C4=CC=C(F)C=C4)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Desfluoro-ezetimibeKeap1-Nrf2AutophagyEzetimibedesfluoroimpurityantihyperlipidemiccholesterolabsorptionNPC1L1Nrf2Inhibitorinhibitorinhibit

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Desfluoro-ezetimibe
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