302781-98-2
302781-98-2
Chemical Structure
Desfluoro-ezetimibe
- CAS No.: 302781-98-2
- Formula:C24H22FNO3
- Molecular Weight:391.43
IUPAC Name: (3R,4S)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)-1-phenylazetidin-2-one
InChIKey: YWZUFJFIXFJKBD-XPWALMASSA-N
SMILES: O=C1N(C2=CC=CC=C2)[C@H](C3=CC=C(O)C=C3)[C@H]1CC[C@@H](C4=CC=C(F)C=C4)O
Biological Activity: Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Desfluoro-ezetimibe | 99.54% | Desfluoro-ezetimibe is a desfluoro impurity of Ezetimibe. Ezetimibe is a potent, metabolically stable cholesterol absorption inhibitor. Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator. | ||||||||||||||||||||
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References
- [1]. Bellur Atici E, et al. Identification, synthesis and characterization of process related desfluoro impurity of ezetimibe and HPLC method validations. J Pharm Anal. 2015 Dec;5(6):356-370. [Content Brief]
- [2]. Lee DH, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016 Sep 12;99:520-532. [Content Brief]
