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O-GlcNAc

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Peptides

1

Natural
Products

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Isotope-Labeled Compounds

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-139793
    UDP-glucosamine disodium

    		Endogenous Metabolite Metabolic Disease
    UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .
    UDP-glucosamine disodium
  • HY-119738
    OSMI-1
    10+ Cited Publications

    		 Acyltransferase Metabolic Disease
    OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
    OSMI-1
  • HY-114361
    OSMI-4
    10+ Cited Publications

    		 Acyltransferase Metabolic Disease
    OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
    OSMI-4
  • HY-112174
    UDP-GlcNAc disodium
    3 Publications Verification

    UDP-α-D-N-Acetylglucosamine disodium

    		 Others Metabolic Disease
    UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).
    UDP-<em>GlcNAc</em> disodium
  • HY-148240
    JNJ-65355394

    		Others Neurological Disease
    JNJ-65355394 (Compound 28) is an O-GlcNAc hydrolase (OGA) inhibitor .
    JNJ-65355394
  • HY-12588
    Thiamet G
    Maximum Cited Publications
    19 Publications Verification

    		 Autophagy Cancer
    Thiamet G is a potent and selective inhibitor of O-GlcNAcase (OGA), which acts to remove O-GlcNAc from modified proteins, with Ki of 20 nM for human OGA.
    Thiamet G
  • HY-136282
    OGT-IN-2

    		Acyltransferase Metabolic Disease
    OGT-IN-2 (compound 4) is a potent O-GlcNAc transferase (OGT) inhibitor, with IC50 values of 30 and 53 μM for sOGT and ncOGT, respectively .
    OGT-IN-2
  • HY-148113
    PG 34

    		Others Others
    PG 34 is a weak O-GlcNAc transferase (OGT) inhibitor (IC50=68 μM), and a close structural analog of OSMI-1 (HY-119738) .
    PG 34
  • HY-112174S
    UDP-GlcNAc-13C disodium

    UDP-α-D-N-Acetylglucosamine-13C disodium

    		 Isotope-Labeled Compounds Metabolic Disease
    UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O[1][2].
    UDP-<em>GlcNAc</em>-13C disodium
  • HY-119738A
    (Rac)-OSMI-1

    		Acyltransferase Metabolic Disease
    (Rac)-OSMI-1 is the racemate of OSMI-1. OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
    (Rac)-OSMI-1
  • HY-W039921
    2-[(Azidoacety)amino]-2-deoxy-D-galactose

    N-Azidoacetylgalactosamine; GalNAz

    		 Biochemical Assay Reagents Others
    2-[(Azidoacety)amino]-2-deoxy-D-galactose targets O-GlcNAc-modified proteins. By detecting and targeting O-GlcNAc-modified proteins, 2-[(Azidoacety)amino]-2-deoxy-D-galactose can serve as a chemical tag for intracellular sugar chain metabolism .
    2-[(Azidoacety)amino]-2-deoxy-D-galactose
  • HY-135785
    OSMI-3

    		Acyltransferase Metabolic Disease
    OSMI-3 (Compound 2b) is a potent, long-lasting, and cell-permeable O-linked N-acetylglucosamine transferase (OGT) inhibitor. Cells contain a large nuclear pool of partially spliced OGT transcript, and OSMI-3 increases detained intron splicing in cells .
    OSMI-3

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