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Pathways Recommended: PROTAC
Results for "

PROTAC CRBN ligand-3

" in MedChemExpress (MCE) Product Catalog:

5

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Click Chemistry

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Cat. No. Nombre del producto Target Áreas de investigación Chemical Structure
  • HY-103597
    Thalidomide-O-COOH
    2 Publications Verification

    Cereblon ligand 3; E3 ligase ligand 3

    		 Ligands for E3 Ligase Cancer
    Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-O-COOH
  • HY-159164
    PROTAC CRBN ligand-3

    		Ligands for Target Protein for PROTAC Cancer
    PROTAC CRBN ligand-3 is a target protein ligand of RGB110 (HY-159087).
    PROTAC CRBN ligand-3
  • HY-175459
    PROTAC FAK degrader 3

    		PROTACs FAK Inflammation/Immunology Cancer
    PROTAC FAK degrader 3 is a selective FAK PROTAC degrader (DC50 = 1.08 nM). PROTAC FAK degrader 3 induces FAK degradation dependent on the ubiquitin-proteasome system and its binding to FAK and CRBN. PROTAC FAK degrader 3 upregulates MHC-I gene transcription and tumor cell surface expression by inhibiting the non-catalytic activity of FAK, leading to increased antigen presentation and activation of cytotoxic CD8 T cells. PROTAC FAK degrader 3 enhances in vivo anti-tumor activity by promoting MHC-I expression and enhancing T cell activation. PROTAC FAK degrader 3 can be used in cancer research targeting FAK degradation in ovarian cancer, hepatocellular carcinoma, and other cancers. (Pink: FAK-IN-3:HY-143407, Blue: Thalidomide-4-OH:HY-103596, Blue + Black: FAK ligand-3: HY-W939883, Black: Linker) .
    PROTAC FAK degrader 3
  • HY-130952
    Thalidomide-O-C8-COOH

    		E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis Cancer
    Thalidomide-O-C8-COOH is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-C8-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-O-C8-COOH
  • HY-103597R
    Thalidomide-O-COOH (Standard)

    Cereblon ligand 3 (Standard); E3 ligase ligand 3 (Standard)

    		 Ligands for E3 Ligase Reference Standards Cancer
    Thalidomide-O-COOH (Standard) is the analytical standard of Thalidomide-O-COOH (HY-103597). This product is intended for research and analytical applications. Thalidomide-O-COOH (Cereblon ligand 3) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide-O-COOH (Cereblon ligand 3) can be connected to the ligand for protein by a linker to form PROTACs .
    Thalidomide-O-COOH (Standard)

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