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ROL

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

1

Peptides

6

Inhibitory Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-16900
    Rolipram
    Maximum Cited Publications
    18 Publications Verification

    (R,S)-ROLipram; (±)-ROLipram; ZK 62711

    		 Phosphodiesterase (PDE) Bacterial HIV Neurological Disease Cancer
    Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    Rolipram
  • HY-14751
    Rolapitant

    SCH619734

    		 Neurokinin Receptor Neurological Disease
    Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .
    Rolapitant
  • HY-16900A
    (R)-(-)-Rolipram
    2 Publications Verification

    (R)-ROLipram; (-)-ROLipram

    		 Phosphodiesterase (PDE) Neurological Disease
    (R)-(-)-Rolipram is the R-enantiomer of Rolipram. Rolipram is a selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    (R)-(-)-Rolipram
  • HY-18257
    Rolitetracycline

    		Antibiotic Bacterial Dengue Virus Amyloid-β HIV Integrase Infection Neurological Disease Inflammation/Immunology
    Rolitetracycline is a highly soluble, broad-spectrum antibiotic derived from tetracycline. Rolitetracycline binds to and stabilizes bovine serum albumin, and also inhibits HIV-1 integrase, blocks Aβ fibril formation and suppresses dengue virus proliferation. Rolitetracycline mediates the inhibition of Aβ fibrils via a specific three-dimensional pharmacophore conformation, and exerts bacteriostatic and bactericidal activities. Rolitetracycline acts synergistically with Penicillin G (HY-N7139) or Cephalothin (HY-B1275A) to alter the effects on microbial growth. Rolitetracycline serves as an important tool compound for the study of bacterial infections (urinary tract infections, sepsis), HIV-1 and dengue virus infections, as well as Alzheimer's disease .
    Rolitetracycline
  • HY-19469
    Roluperidone
    1 Publications Verification

    CYR-101; MIN-101; MT-210

    		 5-HT Receptor Sigma Receptor Neurological Disease
    Roluperidone (CYR-101) is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).
    Roluperidone
  • HY-16436
    Rolapitant hydrochloride hydrate

    SCH619734 hydrochloride hydrate

    		 Neurokinin Receptor Neurological Disease Cancer
    Rolapitant hydrochloride hydrate (SCH619734 hydrochloride hydrate) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride hydrate does not interact with CYP3A4. Rolapitant hydrochloride hydrate shows potent anti-emetic activity in a ferret emesis model .
    Rolapitant hydrochloride hydrate
  • HY-B0392
    (S)-(+)-Rolipram

    (+)-ROLipram; (S)-ROLipram

    		 Phosphodiesterase (PDE) Apoptosis Neurological Disease Inflammation/Immunology Cancer
    (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells .
    (S)-(+)-Rolipram
  • HY-P99238
    Rolinsatamab

    		ADC Antibody Inflammation/Immunology Cancer
    Rolinsatamab is a IgG1κ type chimeric antibody targeting to PRLR (prolactin receptor). Rolinsatamab can be conjugated with pyrrolobenzodiazepine (PDB) dimer SGD-1882 (HY-101127) via a cleavable maleimidocaproyl type linker, to form an antibody-drug conjugate, Rolinsatamab talirine. One Rolinsatamab talirine has an average of 2 site-specific drug attachment engineered cysteines (S239C). The linker equips the valine-alanine dipeptide, as cathepsine B cleavage site. on an average of 2 site-specific drug attachment engineered cysteines (S239C) .
    Rolinsatamab
  • HY-148797
    Rolusafine

    		Fungal Infection
    Rolusafine is an antifungal agent.
    Rolusafine
  • HY-10965
    Rolofylline

    KW-3902

    		 Adenosine Receptor Neurological Disease
    Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450) . Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases .
    Rolofylline
  • HY-P990092
    Rolistobart

    		LILRB Transmembrane Glycoprotein Cancer
    Rolistobart is a humanized immunoglobulin G4-kappa, anti-LILRB4/CD85k monoclonal antibody. Rolistobart is an immunostimulant and antineoplastic .
    Rolistobart
  • HY-112267A
    (R)-Olacaftor

    (R)-VX-440

    		 CFTR Others
    (R)-Olacaftor ((R)-VX-440) is a Cystic fibrosis transmembrane conductance regulator (CFTR) modulator. (R)-Olacaftor has good potential for the study of cystic fibrosis (CF) .
    (R)-Olacaftor
  • HY-W017742
    Rolapitant Intermediate

    (3R,7aR)-3-(tert-Butyl)-1-hydroxy-7a-vinyltetrahydropyrROLo[1,2-c]oxazol-5(3H)-one

    		 Drug Intermediate Others
    Rolapitant Intermediate ((3R,7aR)-3-(tert-Butyl)-1-hydroxy-7a-vinyltetrahydropyrrolo[1,2-c]oxazol-5(3H)-one) is a drug intermediate for synthesis of various active compounds.
    Rolapitant Intermediate
  • HY-16900R
    Rolipram (Standard)

    (R,S)-ROLipram (Standard); (±)-ROLipram (Standard); ZK 62711 (Standard)

    		 Reference Standards Phosphodiesterase (PDE) Bacterial HIV Neurological Disease Cancer
    Rolipram (Standard) is the analytical standard of Rolipram. This product is intended for research and analytical applications. Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
    Rolipram (Standard)
  • HY-119602
    Rolziracetam

    CI-911

    		 Drug Derivative Neurological Disease
    Rolziracetam is a nootropic agent of the racetam family and improves short-term memory in rats and monkeys .
    Rolziracetam
  • HY-P991714
    Roltotatug

    TORL-4-500 antibody

    		 Notch Inflammation/Immunology
    Roltotatug is a humanized IgG1κ antibody targeting DLK1. The corresponding isotype control is: Human IgG1 kappa, Isotype Control (HY-P99001) .
    Roltotatug
  • HY-P99881
    Rolinsatamab talirine

    ABBV 176

    		 Drug-Linker Conjugates for ADC Cancer
    Rolinsatamab talirine (ABBV 176) is an antibody-drug conjugate (ADC) targeting prolactin receptor (PRLR). Rolinsatamab talirine consists of rolinsatamab (HY-P99238), an enzymatically cleavable peptide linker, and SGD-1882 (HY-101127) .
    Rolinsatamab talirine
  • HY-121850
    Rolicyprine

    EX-4883

    		 HBV Neurological Disease
    Rolicyprine (EX-4883) is an antidepressant with neuroprotective activity. Rolicyprine can improve depressive symptoms and promote neuroregeneration. Rolicyprine also shows potential effectiveness for anxiety suppression .
    Rolicyprine
  • HY-18257R
    Rolitetracycline (Standard)

    		Reference Standards Bacterial Antibiotic Infection
    Saflufenacil (Standard) is the analytical standard of Saflufenacil. This product is intended for research and analytical applications. Saflufenacil is a herbicide of the pyrimidinedione chemical class preplant burndown and selective preemergence dicot weed control in multiple crops, including corn. Saflufenacil is a potent inhibitor of protoporphyrinogen IX oxidase (PPO) .
    Rolitetracycline (Standard)
  • HY-14751A
    Rolapitant hydrochloride

    SCH619734 hydrochloride

    		 Neurokinin Receptor Neurological Disease Cancer
    Rolapitant (SCH619734) hydrochloride is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant hydrochloride does not interact with CYP3A4. Rolapitant hydrochloride shows potent anti-emetic activity in a ferret emesis model .
    Rolapitant hydrochloride
  • HY-14751R
    Rolapitant (Standard)

    SCH619734 (Standard)

    		 Reference Standards Neurokinin Receptor Neurological Disease Cancer
    Rolapitant (Standard) is the analytical standard of Rolapitant. This product is intended for research and analytical applications. Rolapitant (SCH619734) is a potent, selective, long-acting and orally active neurokinin 1 (NK1) receptor antagonist with a Ki of 0.66 nM. Rolapitant does not interact with CYP3A4. Rolapitant shows potent anti-emetic activity in a ferret emesis model .
    Rolapitant (Standard)
  • HY-10965R
    Rolofylline (Standard)

    KW-3902 (Standard)

    		 Adenosine Receptor Reference Standards Neurological Disease
    Rolofylline (Standard) is the analytical standard of Rolofylline. This product is intended for research and analytical applications. Rolofylline (KW-3902) is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450) . Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases .
    Rolofylline (Standard)
  • HY-P11675
    Rolzavosoritide

    		Natriuretic Peptide Receptor (NPR) Neurological Disease
    Rolzavosoritide is a C-type natriuretic peptide .
    Rolzavosoritide
  • HY-P992130
    Rolditamig

    TQB2102 Antibody

    		 ADC Antibody EGFR Cancer
    Rolditamig (TQB2102 Antibody) is a recombinant humanized anti-human epidermal growth factor receptor 2 (HER2) antibody. Rolditamig can be conjugated with an enzyme-cleavable linker and a topoisomerase I inhibitor to form the ADC TQB2102. Rolditamig is applicable to research on solid tumors such as HER2-positive breast cancer .
    Rolditamig
  • HY-105265
    Rolafagrel

    FCE 22178

    		 Prostaglandin Receptor Cardiovascular Disease
    Rolafagrel is an inhibitor of thromboxane synthase. Rolafagrel can be studied in cardiovascular research .
    Rolafagrel

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