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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
17 Results for "
Ruxolitinib
" in MedChemExpress (MCE) Product Catalog:
Products (17)
17 Results for "Ruxolitinib" in MCE Product Catalog:
280
Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3 . Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy .
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280 Publications Verification
Cat. No.: HY-50858
CAS No.: 1092939-17-7
Synonyms: INCB018424 phosphate
Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.
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Ruxolitinib (S enantiomer) (S-Ruxolitinib) is the S-enantiomer of Ruxolitinib (HY-50856). Ruxolitinib (S enantiomer) is an orally active, potent JAK inhibitor .
Cat. No.: HY-50856S
CAS No.: 1513883-39-0
Synonyms: CTP-543; Ruxolitinib-d8; INCB18424-d8
Target:
Research Areas:
Deuruxolitinib (CTP-543; Ruxolitinib-d8) is a deuterated analog of Ruxolitinib (HY-50856) and an orally active, selective inhibitor of JAK1 and JAK2. Deuruxolitinib blocks Janus kinase-mediated cytokine receptor signaling and proinflammatory cytokine gene expression. Deuruxolitinib is primarily metabolized in the liver via CYP2C9. Deuruxolitinib promotes scalp hair regrowth in severe chronic alopecia areata. Deuruxolitinib is used in alopecia areata-related research .
Cat. No.: HY-50856R
CAS No.: 941678-49-5
Synonyms: INCB18424 (Standard)
Ruxolitinib (Standard) is the analytical standard of Ruxolitinib. This product is intended for research and analytical applications. Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3 . Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy .
Cat. No.: HY-W062703S
CAS No.: 2469553-67-9
Synonyms: (Rac)-INCB18424-d9; Ruxotinib racemate-d9
Cat. No.: HY-W062703S1
CAS No.: 1794791-38-0
Synonyms: (Rac)-INCB18424-d8; Ruxotinib racemate-d8
Cat. No.: HY-W059210
CAS No.: 952518-97-7
Research Areas:
Ruxolitinib impurity-1 is a pyrrolopyrimidine derivative and also an impurity of Ruxolitinib (HY-50856). Ruxolitinib serves as a synthetic intermediate for TDM-180967, a dual JAK1/Tyk2 inhibitor, and can also be used as an impurity reference standard for drug quality control .
Cat. No.: HY-50859
CAS No.: 1092939-16-6
Synonyms: INCB018424 sulfate
Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
Cat. No.: HY-50856S2
CAS No.: 1513883-55-0
Synonyms: INCB18424-d9
Cat. No.: HY-W722493
CAS No.: 1911644-32-0
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Ruxolitinib-amide (P28 XII) is an amide derivative of the JAK1/2 inhibitor Ruxolitinib (HY-50856) .
Cat. No.: HY-159917
CAS No.: 3040997-52-9
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PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment .
Cat. No.: HY-Z18070S
Cat. No.: HY-50858R
CAS No.: 1092939-17-7
Synonyms: INCB018424 phosphate (Standard)
Target:
Research Areas:
Ruxolitinib phosphate (Standard) is the analytical standard of Ruxolitinib phosphate (HY-50858). This product is intended for research and analytical applications. Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC50s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3.
Cat. No.: HY-Z18070AS
Cat. No.: HY-50856BS
CAS No.: 2147706-60-1
Synonyms: CTP-543 phosphate; Ruxolitinib-d8 phosphate; INCB18424-d8 (phospha
Target:
Research Areas:
Deuruxolitinib phosphate (CTP-543 phosphate; Ruxolitinib-d8 phosphate) is a deuterated analog of Ruxolitinib (HY-50856) and an orally active, selective inhibitor of JAK1 and JAK2. Deuruxolitinib phosphate blocks Janus kinase-mediated cytokine receptor signaling and proinflammatory cytokine gene expression. Deuruxolitinib phosphate is primarily metabolized in the liver via CYP2C9. Deuruxolitinib phosphate promotes scalp hair regrowth in severe chronic alopecia areata. Deuruxolitinib phosphate is used in alopecia areata-related research .
Cat. No.: HY-180561
CAS No.: 3076807-15-0
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Research Areas:
WWQ-03-012 is a selective DESI2 inhibitor with an IC50 of 47.3 nM. WWQ-03-012 binds covalently to DESI2, blocks its enzymatic activity, and inhibits DESI2-mediated deSUMOylation, deubiquitination and stabilization of mutant JAK2, thereby promoting the complete degradation of mutant JAK2 via the intracellular ubiquitin-proteasome system and inducing apoptosis, while exerting no significant effect on wild-type JAK2. WWQ-03-012 can be used for research on myeloproliferative neoplasms (MPN) and secondary acute myeloid leukemia (sAML), especially for hematological malignancies carrying the JAK2-V617F mutation and those resistant to Ruxolitinib (HY-50856) .
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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
