Ruxolitinib (S enantiomer) (Synonyms: S-Ruxolitinib; S-INCB18424)

Cat. No.: HY-50856A Purity: 99.92%
Handling Instructions

Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays.

For research use only. We do not sell to patients.

Ruxolitinib (S enantiomer) Chemical Structure

Ruxolitinib (S enantiomer) Chemical Structure

CAS No. : 941685-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 170 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 252 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

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Description

Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays.

Molecular Weight

306.37

Formula

C₁₇H₁₈N₆

CAS No.

941685-37-6

SMILES

N#CC[[email protected]@H](C1CCCC1)N2N=CC(C3=NC=NC4=C3C=CN4)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (326.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2640 mL 16.3201 mL 32.6403 mL
5 mM 0.6528 mL 3.2640 mL 6.5281 mL
10 mM 0.3264 mL 1.6320 mL 3.2640 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

KeyWords:

Ruxolitinib (S enantiomer) | S-Ruxolitinib | S-INCB18424 | Inhibitor | inhibitor | inhibit

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Ruxolitinib (S enantiomer)
Cat. No.:
HY-50856A
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