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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
YTH
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "YTH" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: 6-Methyladenosine (Standard); N-Methyladenosine (Standard)
Cat. No.: HY-164607
CAS No.: 3056857-07-6
Target:
Research Areas:
YL-5092 is a selective YT521-B homology (YTH) domain-containing protein 1 (YTHDC1) inhibitor with an IC50 of 7.4 nM and a KD of 29.6 nM. YL-5092 can suppress cancer cell proliferation and induce cell G0/G1 phase arrest and apoptosis. YL-5092 can be used for the research of cancer, such as acute myeloid leukemia (AML) .
Cat. No.: HY-176848
SKLB-Y13 is a selective YTHDF1 inhibitor with an IC50 of 0.76 μM and a KD of 5.097 μM. SKLB-Y13 binds to the Tyr397 and Trp470 residues in the m 6A-binding pocket of YTHDF1, disrupting the interaction between YTHDF1 and m 6A-modified mRNA. SKLB-Y13 inhibits cancer cell proliferation and promotes apoptosis. SKLB-Y13 is applicable to breast cancer-related research .
Cat. No.: HY-168610
CAS No.: 2189366-92-3
Target:
Research Areas:
YTH-IN-1 (compound N-7) is a pan-YTH domain inhibitor with the IC50 values of 39 μM, 34 μM, 35 μM, 48 μM and 30 μM for human YTH YTHDF1, YTH YTHDF2, YTH YTHDF3, YTH YTHDC1, and YTH YTHDC2, respectively .
Cat. No.: HY-173008
YTHDF2-IN-1 (Compound CK-75) is a selective YTHDF2 inhibitor (Kd = 26.2 μM). YTHDF2-IN-1 binds to a small hydrophobic pocket on the YTH domain of YTHDF2, disrupting the interaction between YTHDF2 and m 6A-modified RNA. YTHDF2-IN-1 induces cell cycle arrest and Apoptosis. YTHDF2-IN-1 is applicable to research on chronic myeloid leukemia, colon cancer and choriocarcinoma .
Cat. No.: HY-P702576
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: YTHDF2; YTH N6‑Methyladenosine RNA Binding Protein F2; HGRG8; NY‑REN‑2; CAHL; YTH N(6)‑Methyladenosine RNA Binding Protein 2; YTH N6‑Methyladenosine RNA Binding Protein 2; YTH Domain‑Containing Family Protein 2; High‑Glucose‑Regulated Protein 8; Renal Car
Cat. No.: HY-P86545
Synonyms: C20orf21; DACA 1; DACA-1; Dermatomyositis associated with cancer putative autoantigen 1; YTH domain family 1; YTH domain family member 1; YTH domain family protein 1; YTHD1; YTHD1_HUMAN; YTHdf1;
Cat. No.: HY-P87148
Synonyms: KIAA1966 antibody; Putative splicing factor YT521 antibody; splicing factor YT521-B antibody; YT521 antibody; YT521-B antibody; YTDC1_HUMAN antibody; YTH domain-containing protein 1 antibody; YTHDC1 antibody;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
