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antibiotic+resistance

" in MedChemExpress (MCE) Product Catalog:

10

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Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W062216
    2-Aminoimidazole

    		Bacterial Arginase Infection
    2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .
    2-Aminoimidazole
  • HY-B1325
    Cefuroxime axetil

    		Bacterial Antibiotic Infection Inflammation/Immunology
    Cefuroxime axetil is an orally effective broad-spectrum β-lactam antibiotic that targets bacterial penicillin-binding proteins (PBPs, such as PBP3 and PBP1). Cefuroxime axetil inhibits cell wall synthesis, leading to bacterial lysis and death, with a minimum inhibitory concentration (MIC) of 0.12-4 mg/L for non-typeable Haemophilus influenzae (NTHi). Cefuroxime axetil is hydrolyzed by esterase to the active ingredient Cefuroxime (HY-B1256A) after oral absorption. Topical administration of Cefuroxime via bioadhesive nanoparticles (BNPs) can prolong the drug's retention time in the middle ear (≥7 days). Cefuroxime axetil can be used in the study of otitis media (especially NTHi infection). Cefuroxime axetil can achieve precise antibacterial effects through oral or topical nano-delivery systems, reducing systemic exposure and the risk of antibiotic resistance .
    Cefuroxime axetil
  • HY-127146
    Platensimycin

    		Antibiotic Bacterial Infection
    Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.
    Platensimycin
  • HY-146199
    Antibacterial agent 108

    		Bacterial Infection
    Antibacterial agent 108 (Compound 1h) is a potent antibacterial agent with a MIC of both 3 μM against MRSA and antibiotic resistance strains .
    Antibacterial agent 108
  • HY-178101
    WRS22

    		Bacterial Drug Derivative Infection
    WRS22, a derivative of Tirabrutinib (HY-15771), is a bacterial Tryptophanyl-tRNA synthetase (TrpRS) inhibitor with a Kd of 0.33 μM for EcTrpRS. WRS22 can be used for antibiotic resistance research .
    WRS22
  • HY-168799
    3-Methoxy prostaglandin F1α

    		Drug Metabolite Prostaglandin Receptor Endocrinology
    3-Methoxy prostaglandin F1α is an analog of PGF1α that can be metabolized by naturally occurring extracellular antibiotic resistance genes (eARGs) that enter the intestine via the food chain .
    3-Methoxy prostaglandin F1α
  • HY-W062216R
    2-Aminoimidazole (Standard)

    		Reference Standards Bacterial Arginase Infection
    2-Aminoimidazole is a potent antibiofilm agent that can be used as an adjuvant to antimicrobial. 2-aminoimidazoles disrupts the ability of bacteria to protect themselves by inhibiting biofilm formation and genetically-encoded antibiotic resistance traits. 2-Aminoimidazole is also a weak noncompetitive inhibitor of human arginase I with a Ki of 3.6 mM .
    2-Aminoimidazole (Standard)
  • HY-168995
    BAR-072

    		Bacterial Infection
    BAR-072 is a small-molecule inhibitor targeting TraE, with a KD of 2.7 µM. It significantly inhibits the transfer of the antibiotic resistance-associated plasmid pKM101. BAR-072 shows promise as a candidate compound for blocking the spread of bacterial resistance genes and holds potential for research in infectious disease and antimicrobial resistance control .
    BAR-072
  • HY-155504
    Metallo-β-lactamase-IN-11

    		Beta-lactamase Bacterial Infection
    Metallo-β-lactamase-IN-11 (compound 5f) is a Metallo-β-lactamases (MBLs) inhibitor, potent against bacterial metallophyllactamase CphA (IC50=45 µM). Metallo-β-lactamase-IN-11 (10 µM) inhibits NDM-1 by 49% and AIM-1 by 61%. Metallo-β-lactamase-IN-11 can be used in the research of inhibiting antibiotic resistance .
    Metallo-β-lactamase-IN-11
  • HY-179719
    Anti-MRSA agent 41

    		Bacterial Drug Intermediate Infection
    Anti-MRSA agent 41 (Compound 3d) is a prodrug of Mupirocin (HY-B0958), being a cholesterol disulfide conjugate of Mupirocin. Anti-MRSA agent 41 shows no antibacterial activity or cytotoxicity in vitro. Anti-MRSA agent 41 demonstrates strong anti-MRSA infection efficacy in systemic bacteremia and pneumonia mouse models. Anti-MRSA agent 41 can be used in antibiotic resistance research .
    Anti-MRSA agent 41

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