1. Anti-infection
  2. Antibiotic
    Bacterial
  3. Platensimycin

Platensimycin 

Cat. No.: HY-127146
Handling Instructions

Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.

For research use only. We do not sell to patients.

Platensimycin Chemical Structure

Platensimycin Chemical Structure

CAS No. : 835876-32-9

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Description

Platensimycin is an antibiotic produced by S. platensis that inhibits gram-positive bacteria by selectively inhibiting cellular lipid biosynthesis (IC50=0.1 μM). Platensimycin targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s=48 nM and 160 nM for S.aureus and E.coli enzymes, respectively). Platensimycin is a promising agent for overcoming antibiotic resistance.

Molecular Weight

441.47

Formula

C₂₄H₂₇NO₇

CAS No.

835876-32-9

SMILES

O=C(O)C1=CC=C(O)C(NC(CC[[email protected]]([[email protected]@]2([H])[[email protected]]34C[[email protected]]5([H])[[email protected]@](C4)(C)O[[email protected]@]2([H])C5)(C)C(C=C3)=O)=O)=C1O

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Keywords:

PlatensimycinAntibioticBacterialInhibitorinhibitorinhibit

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Platensimycin
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HY-127146
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