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bay+7

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By Targets:	ADC Antibody (1) Carbonic Anhydrase (1) Deubiquitinase (1) DNA/RNA Synthesis (2) Fluorescent Dye (1) GnRH Receptor (1) Guanylate Cyclase (1) Histone Acetyltransferase (1) Isotope-Labeled Compounds (1) MMP (1) Phosphodiesterase (PDE) (3)
By Research Areas:	Cancer (6) Cardiovascular Disease (4) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (1)

Inhibitors & Agonists

Inhibitory Antibodies

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-112081

BAY-707	DNA/RNA Synthesis	Cancer
BAY-707, a chemical probe, is a substrate-competitive, highly potent and selective inhibitor of MTH1(NUDT1) with an IC₅₀ of 2.3 nM. BAY-707 has a good pharmacokinetic (PK) profile to other MTH1 compounds and is well-tolerated in mice, but shows a clear lack of in vitro or in vivo anticancer efficacy .

HY-133080

BAY-784	GnRH Receptor	Cancer
BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC₅₀s of 21 and 24 nM for human and rat GnRH-R, respectively .

HY-153045A

BAY-728	Deubiquitinase	Cancer
BAY-728 can be used as a negative control of BAY-805. BAY-805 is a potent and selective Inhibitor of USP21 .

HY-153369

BAY-747 BAY 1165747	Guanylate Cyclase	Cardiovascular Disease Neurological Disease
BAY-747 (BAY 1165747) is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model .

HY-152106

BAY-7081 1 Publications Verification	Phosphodiesterase (PDE)	Cardiovascular Disease
BAY-7081, a chemical probe, is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC₅₀ of 15 nM .

HY-156965

BAY-771	Fluorescent Dye	Metabolic Disease Cancer
BAY-771, a structurally close pyrimidinedione, is a chemical probe with good lead-like properties and high permeability in Caco-2 cells (no hint of efflux). BAY-771 shows very weak inhibitory activity in the BCAT1 biochemical assay and no activity in BCAT2. BAY-771 can be used as a negative control of HY-148242 BAY-069. BAY-771 can be used for the research of tumor metabolism .

HY-152106B

(±)-BAY-7081	Phosphodiesterase (PDE)	Cardiovascular Disease
(±)-BAY-7081 is a racemate of BAY-7081 (HY-152106). BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC₅₀ of 15 nM .

HY-152106A

(+)-BAY-7081	Phosphodiesterase (PDE)	Cardiovascular Disease
(+)-BAY-7081 is an optical isomer of BAY-7081 (HY-152106). BAY-7081 is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC₅₀ of 15 nM .

HY-120944

BAY-7598	MMP	Inflammation/Immunology
BAY-7598, a chemical probe, is a potent, orally bioavailable, and selective MMP12 inhibitor with IC₅₀s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively .

HY-112081A

BAY-707 acetate	DNA/RNA Synthesis	Others
BAY-707 acetate is a highly potent and selective substrate-competitive inhibitor of MTH1 with superior cellular target engagement and pharmacokinetic properties.

HY-183256

BAY-7728	Histone Acetyltransferase	Cancer
BAY-7728 is an orally active and selective dual inhibitor of KAT6A (IC₅₀: 45 nM)/KAT6B (IC₅₀: 95 nM). BAY-7728 can effectively inhibit tumor growth and regulate the acetylation level of histone H3K23. BAY-7728 can be used for tumor research.

HY-P992322

BAY-79-4620 Antibody	ADC Antibody Carbonic Anhydrase	Cancer
BAY-79-4620 Antibody is a potent and selective CAIX antibody with a human CAIX K_d of 3.6 nM. BAY-79-4620 Antibody yields antibody-drug conjugate (ADC) through conjugating with Monomethyl auristatin E (HY-15162) via a self-immolative enzyme-cleavable linker. BAY-79-4620 Antibody can be used for the research of cervical carcinoma, non-small cell lung carcinoma, breast carcinoma, pancreatic carcinoma, gastric carcinoma, prostate carcinoma .

HY-120422S1

Regorafenib M4 metabolite-13C6 BAY-751098-¹³C₆; N-Desmethyl Regorafenib-¹³C₆	Isotope-Labeled Compounds	Others
Regorafenib M4 metabolite- ¹³C₆ (BAY-751098- ¹³C₆) is the ¹³C-labeled Regorafenib M4 metabolite.

Cat. No.	Product Name	Target	Research Area	Image

HY-P992322

BAY-79-4620 Antibody	ADC Antibody Carbonic Anhydrase	Cancer
BAY-79-4620 Antibody is a potent and selective CAIX antibody with a human CAIX K_d of 3.6 nM. BAY-79-4620 Antibody yields antibody-drug conjugate (ADC) through conjugating with Monomethyl auristatin E (HY-15162) via a self-immolative enzyme-cleavable linker. BAY-79-4620 Antibody can be used for the research of cervical carcinoma, non-small cell lung carcinoma, breast carcinoma, pancreatic carcinoma, gastric carcinoma, prostate carcinoma .

Regorafenib M4 metabolite-13C6
Regorafenib M4 metabolite- ¹³C₆ (BAY-751098- ¹³C₆) is the ¹³C-labeled Regorafenib M4 metabolite.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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