BAY-7081
Based on 1 publication(s) in Google Scholar
BAY-7081, a chemical probe, is a potent, selective, orally active and soluble cyanopyridone-based PDE9A inhibitor with an IC50 of 15 nM.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.03%
- No. CAS: 3036022-06-4
- Fòrmula: C19H27ClN4O
- Peso molecular:362.90
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Almacenamiento:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) BAY-7081
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
PDE9A 15 nM (IC50) |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Wistar rats and dogs[1]
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Dosage:0.3 or 1.0 mg/kg
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Administration:Intravenous injection or oral (Pharmacokinetic Analysis)
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Result:PK Profile of PDE9A Inhibitor BAY-7081 in Selected Speciesa[1]
species CLbb [L h–1 kg–1] VSSc [L kg–1] MRTd [h] Fe [%] Rat 2.4 4.5 1.9 61 Dog 0.9 3.0 4.0 80
a Values were derived by intravenous (dose 0.3 mg/kg) and oral (dose 1.0 mg/kg) administration of solutions in either plasma 99% + DMSO 1% (rat iv) or EtOH/PEG400/H2O (dog iv, rat and dog po) vehicles.
bBlood clearance.
cVolume of distribution at steady state.
dMean residence time after iv application.
eOral bioavailability.
Chemical Information
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No. CAS 3036022-06-4
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Appearance Solid
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Peso molecular 362.90
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Fòrmula C19H27ClN4O
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Color White to off-white
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SMILES
N#CC1=C(N(CC2)CCC32CC3)C4=C(NC1=O)C(CCC)CNC4.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Int J Biol Macromol
2026 Feb:347:150597. PMID: 41643971
Solvente y solubilidad
In Vitro:
DMSO : 33.33 mg/mL (91.84 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (6.89 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (6.89 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.7556 mL | 13.7779 mL | 27.5558 mL | 68.8895 mL |
| 5 mM | 0.5511 mL | 2.7556 mL | 5.5112 mL | 13.7779 mL | |
| 10 mM | 0.2756 mL | 1.3778 mL | 2.7556 mL | 6.8890 mL | |
| 15 mM | 0.1837 mL | 0.9185 mL | 1.8371 mL | 4.5926 mL | |
| 20 mM | 0.1378 mL | 0.6889 mL | 1.3778 mL | 3.4445 mL | |
| 25 mM | 0.1102 mL | 0.5511 mL | 1.1022 mL | 2.7556 mL | |
| 30 mM | 0.0919 mL | 0.4593 mL | 0.9185 mL | 2.2963 mL | |
| 40 mM | 0.0689 mL | 0.3444 mL | 0.6889 mL | 1.7222 mL | |
| 50 mM | 0.0551 mL | 0.2756 mL | 0.5511 mL | 1.3778 mL | |
| 60 mM | 0.0459 mL | 0.2296 mL | 0.4593 mL | 1.1482 mL | |
| 80 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8611 mL |
BAY-7081 Related Classifications
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