BAY-747

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BAY-747 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model.

For research use only. We do not sell to patients.

BAY-747 Chemical Structure

CAS No. : 1609342-18-8

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5 mg	USD 1050	Ask For Quote & Lead Time
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25 mg	USD 3400	Ask For Quote & Lead Time
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Description

IC₅₀ & Target

Soluble guanylate cyclase (sGC)^[1]

In Vitro

BAY-747 (100 nM) enhances AMPA receptor dynamics in an ex vivo acquisition-like cLTP model, in combination with WS^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	ex vivo acquisition-like cLTP model
Concentration:	100 nM
Incubation Time:
Result:	Increased the phosphorylation levels of S845 on GluA1.

In Vivo

BAY-747 shows a brain to plasma ratio of 0.6 ± 2.0 at the investigated time frame, reflecting a relatively high brain penetration of 60%^[1].
BAY-747 (0.03-1.0 mg/kg,2 mL/kg ; po; 30 min before T1 in a 24 h interval OLT) enhance long-term memory acquisition processes in rat object location task (OLT) model, and also attenuates L-NAME induced short-term memory impairments. BAY-747 does not affect GluA1-containing AMPAR dynamics in the hippocampus^[1].
BAY-747 (0.003-0.3 mg/kg; po; single dose) decreases blood pressure in rats, and also (3 mg/kg; po; once daily for 35 days) increases body weight of rats in l-NAME-Treated Renin Transgenic model^[2].
BAY-747 (150 mg/kg of food; po; 16 weeks) improves grip strength and running speed in male mdx/mTRG2 mice, suggesting improved skeletal muscle function^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rat object location task (OLT) model^[1]
Dosage:	0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, 0.3 mg/kg, 1 mg/kg, 3 mg/kg
Administration:	PO; 30 min before T1 in a 24 h interval OLT
Result:	Resulted significantly higher long-term memory performance at 0.03, 0.1, 0.3 and 1.0 mg/kg dose, 30 min before T1. Attenuated L-NAME induced short-term memory impairments at 0.3 mg/kg and 1 mg/kg. Did not enhance GluA1 trafficking at 1 mg/kg 24 h after treatment.

Animal Model:	Anesthetized, conscious spontaneously hypertensive and conscious normotensive rats^[2]
Dosage:	0 mg/kg, 0.003 mg/kg, 0.01 mg/kg, 0.03 mg/kg, 0.1 mg/kg, and 0.3 mg/kg
Administration:	IV; single dose
Result:	Produced a dose-dependent and long-lasting decrease in blood pressure in rats.

Animal Model:	l-NAME-Treated Renin Transgenic Rats^[2]
Dosage:	0.3 mg/kg, 3 mg/kg
Administration:	PO; once daily for 35 days; l-NAME treatment: 30 mg/kg, po, for 6 days
Result:	Resulted a significant weight gain among rats. Led to a dose-dependent increase of plasma cGMP. Decreased blood pressure only at 3 mg/kg.

Molecular Weight

416.46

Formula

C₂₂H₂₆F₂N₄O₂

CAS No.

1609342-18-8

SMILES

FC(C=CC=C1F)=C1COC2=CC(C)=CN3C2=NC(C)=C3C(NC[C@@](C)(N)CC)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nelissen E, et al. The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms. Sci Rep. 2022 Mar 4;12(1):3589. [Content Brief]

[2]. Vakalopoulos A, et al. New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension. J Med Chem. 2023 Apr 11. [Content Brief]

[3]. Krishnan SM, et al. Assessing the Use of the sGC Stimulator BAY-747, as a Potential Treatment for Duchenne Muscular Dystrophy. Int J Mol Sci. 2021 Jul 27;22(15):8016. [Content Brief]

BAY-747 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-7471609342-18-8BAY747BAY 747Guanylate CyclaseInhibitorinhibitorinhibit

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