2. GPCR/G Protein
  3. GnRH Receptor
  4. BAY-784

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.

For research use only. We do not sell to patients.

BAY-784

BAY-784 Chemical Structure

CAS No. : 1631164-24-3

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5 mg In-stock
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50 mg   Get quote  

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Description

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].

IC50 & Target

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]
In Vivo

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OVX rats[1]
Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration: Single p.o.
Result: ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
Molecular Weight

672.11

Formula

C29H26ClF4N3O5S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (59.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4879 mL 7.4393 mL 14.8785 mL
5 mM 0.2976 mL 1.4879 mL 2.9757 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.5%

SDS (251 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4879 mL 7.4393 mL 14.8785 mL 37.1963 mL
5 mM 0.2976 mL 1.4879 mL 2.9757 mL 7.4393 mL
10 mM 0.1488 mL 0.7439 mL 1.4879 mL 3.7196 mL
15 mM 0.0992 mL 0.4960 mL 0.9919 mL 2.4798 mL
20 mM 0.0744 mL 0.3720 mL 0.7439 mL 1.8598 mL
25 mM 0.0595 mL 0.2976 mL 0.5951 mL 1.4879 mL
30 mM 0.0496 mL 0.2480 mL 0.4960 mL 1.2399 mL
40 mM 0.0372 mL 0.1860 mL 0.3720 mL 0.9299 mL
50 mM 0.0298 mL 0.1488 mL 0.2976 mL 0.7439 mL
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BAY-784 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-7841631164-24-3BAY784BAY 784GnRH ReceptorGonadotropin releasing hormone receptorGNRHRGnRH-RprobeInhibitorinhibitorinhibit

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