BAY-784
Based on 1 Customer Validation
BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.
For research use only. We do not sell to patients.
- Purity: 99.5%
- CAS No.: 1631164-24-3
- Formula: C29H26ClF4N3O5S2
- Molecular Weight:672.11
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OVX rats[1]
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Dosage:0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
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Administration:Single p.o.
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Result:ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
Chemical Information
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CAS No. 1631164-24-3
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Appearance Solid
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Molecular Weight 672.11
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Formula C29H26ClF4N3O5S2
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Color White to off-white
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SMILES
O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 40 mg/mL (59.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4879 mL | 7.4393 mL | 14.8785 mL | 37.1963 mL |
| 5 mM | 0.2976 mL | 1.4879 mL | 2.9757 mL | 7.4393 mL | |
| 10 mM | 0.1488 mL | 0.7439 mL | 1.4879 mL | 3.7196 mL | |
| 15 mM | 0.0992 mL | 0.4960 mL | 0.9919 mL | 2.4798 mL | |
| 20 mM | 0.0744 mL | 0.3720 mL | 0.7439 mL | 1.8598 mL | |
| 25 mM | 0.0595 mL | 0.2976 mL | 0.5951 mL | 1.4879 mL | |
| 30 mM | 0.0496 mL | 0.2480 mL | 0.4960 mL | 1.2399 mL | |
| 40 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9299 mL | |
| 50 mM | 0.0298 mL | 0.1488 mL | 0.2976 mL | 0.7439 mL |
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