2. GPCR/G Protein
  3. GnRH Receptor
  4. BAY-784

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively.

For research use only. We do not sell to patients.

BAY-784 Chemical Structure

BAY-784 Chemical Structure

CAS No. : 1631164-24-3

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Based on 1 publication(s) in Google Scholar

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Description

BAY-784 is a gonadotropin releasing hormone receptor (GnRH-R) antagonist probe with IC50s of 21 and 24 nM for human and rat GnRH-R, respectively[1].

IC50 & Target

IC50: 21 nM (human GnRH-R), 24 nM (rat GnRH-R)[1]
In Vivo

BAY-784 (0.5, 3, 10, and 30 mg/kg; 24 hours; single p.o.) suppresses the plasma luteinizing hormone (LH) concentration in ovariectomized (OVX) rats in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: OVX rats[1]
Dosage: 0.5, 3, 10, and 30 mg/kg (Pharmacokinetic Analysis)
Administration: Single p.o.
Result: ED50=4.5 mg/kg (4/8 h).
The t1/2=13-17 h, 18 h, and 7 h for male Wistar rat, female beagle, and female cynomolgus, respectively.
Molecular Weight

672.11

Formula

C29H26ClF4N3O5S2
CAS No.
SMILES

O=C(C1=CC2=C(N(S(=O)(C3=CC=C(F)C=C3)=O)[C@@H](C4CC4)C2(CC5)CCS5(=O)=O)C=C1)NCC6=NC=C(C(F)(F)F)C=C6Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY-784 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY-7841631164-24-3BAY784BAY 784GnRH ReceptorGonadotropin releasing hormone receptorGNRHRGnRH-RprobeInhibitorinhibitorinhibit

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HY-133080
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