1. Metabolic Enzyme/Protease
  2. MMP
  3. BAY-7598

BAY-7598 

Cat. No.: HY-120944
Handling Instructions

BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively.

For research use only. We do not sell to patients.

BAY-7598 Chemical Structure

BAY-7598 Chemical Structure

CAS No. : 1816257-74-5

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Description

BAY-7598 is a potent, orally bioavailable, and selective MMP12 inhibitor probe with IC50s of 0.085, 0.67 and 1.1 nM for human MMP12, murine MMP12, and rat MMP12, respectively[1].

IC50 & Target

IC50: 0.085 nM (human MMP12), 0.67 nM (murine MMP12), 1.1 nM (rat MMP12)[1]

In Vitro

BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 with IC50s of 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM, respectively[1].
BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 with IC50s of 45, 270, 130, 54, and 210 nM, respectively[1].
BAY-7598 inhibits rat MMP2, MMP8, and MMP9 with IC50s of 45, 67, and 1000 nM, respectively[1].

In Vivo

BAY-7598 has moderate terminal elimination half-life (t1/2=4.6 h and 4.1 h for mouse (0.3 mg/kg, iv), mouse (5.0 mg/kg, p.o.) , respectively)[1].

Animal Model: Mouse[1]
Dosage: 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.)
Administration: Administered i.v. (0.3 mg/kg) and p.o. (5.0 mg/kg) (Pharmacokinetic Analysis)
Result: T1/2=4.6 h and 4.1 h for 0.3 mg/kg (i.v.) and 5.0 mg/kg (p.o.), respectively.
Molecular Weight

505.56

Formula

C₂₈H₃₁N₃O₆

CAS No.

1816257-74-5

SMILES

O=C([[email protected]]1[[email protected]](CN2N=NC3=CC=CC=C3C2=O)CC[[email protected]@H]1C(C4=CC=C(OCCC5CCOCC5)C=C4)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BAY-7598BAY7598BAY 7598MMPMatrix metalloproteinasesBAY-7598 is a potentorally bioavailableand selective MMP12 inhibitor probe with IC50s of 0.0850.67 and 1.1 nM for human MMP12murine MMP12and rat MMP12respectively. Anti-inflammation activity[1].Inhibitorinhibitorinhibit

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