branched-chain fatty acid

By Targets:	Apoptosis (2) Bacterial (1) Biochemical Assay Reagents (4) Endogenous Metabolite (6) Isotope-Labeled Compounds (1) Reference Standards (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Infection (1) Metabolic Disease (4)

Targets Recommended: Branched Chain Amino Acid Transaminase (BCAT) Free Fatty Acid Receptor Fatty Acid Synthase (FASN) FATP FABP FAAH ELOVL

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015874

2-Hydroxy-2-methylbutanoic acid	Endogenous Metabolite	Metabolic Disease
2-Hydroxy-2-methylbutanoic acid is a branched-chain fatty acid. 2-Hydroxy-2-methylbutanoic acid accumulates at high levels in the culture supernatants of colorectal cancer-associated bacteria. 2-Hydroxy-2-methylbutanoic acid is also present in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease .

HY-W010516

2-Methylvaleric acid 2-Methylpentanoic acid	Endogenous Metabolite	Metabolic Disease
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Apoptosis	Cancer
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-155157

PF-07247685	Endogenous Metabolite	Cardiovascular Disease
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-128371

2-Methylhexanoic acid	Biochemical Assay Reagents	Others
2-Methylhexanoic acid is a saturated branched-chain carboxylic acid with a strong "fatty" or "oily" odor. At high concentrations, it is often described as having the smell of lard, chicken fat or sweat; when diluted, it exhibits a dairy, cream or cheese aroma. Therefore, it is commonly used in the formulation of milk, meat (pork/chicken) and baked food flavors. 2-Methylhexanoic acid occurs naturally in fresh apples, cheese, grape brandy, lamb, potatoes and tea .

HY-121950

18-Methyleicosanoic acid	Biochemical Assay Reagents	Others
18-Methyleicosanoic acid is a branched-chain fatty acid. 18-Methyleicosanoic acid has a hydrophobic surface and can act as a boundary lubricant .

HY-155156

PF-07238025	Endogenous Metabolite	Cardiovascular Disease
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC₅₀=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-111487

α-Methylacyl-CoA racemase 1	Endogenous Metabolite	Metabolic Disease Cancer
α-methylacyl-CoA racemase 1 is an enzyme that catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, and used as a maker in prostate and other cancer.

HY-131503S

13-Methyltetradecanoic acid-d6 13-MTD-d₆; 13-Methylmyristic acid-d₆	Isotope-Labeled Compounds Apoptosis	Cancer
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-W1005647

(rac)-Isoleucine	Biochemical Assay Reagents	Others
(rac)-Isoleucine is the racemic form of Isoleucine. Isoleucine is a mixture of the diastereomers L-isoleucine, L-alloisoleucine, D-isoleucine, and D-alloisoleucine. L-isoleucine is a branched-chain amino acid that acts as a nitrogen donor, and has roles in glucose consumption, fatty acid metabolism, as well as immune function. L-Alloisoleucine is generated by transamination of L-isoleucine. D-Isoleucine and D-alloisoleucine are enantiomers of L-isoleucine and L-alloisoleucine, respectively .

HY-W010516R

2-Methylvaleric acid (Standard) 2-Methylpentanoic acid (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-W143057

2-Methylhexadecanoic acid	Biochemical Assay Reagents	Others
2-Methylhexadecanoic acid is a C17 branched-chain fatty acid and can be used as a branched fatty acid feedstock for transesterification .

HY-183968

BRD1554	Bacterial	Infection
BRD1554 is an inhibitor of the thioesterase domain of polyketide synthase 13 (Pks13) from Mycobacterium tuberculosis, and exhibits selective activity against Pks13-expressing strains. Pks13 is a polyketide synthase essential for the synthesis of branched-chain fatty acids in mycobacteria. BRD1554 serves as a scaffold molecule for anti-Mycobacterium tuberculosis agents. BRD1554 can be used in the research of tuberculosis .

Cat. No.	Product Name	Type

HY-W127484

Isopalmitic acid 14-Methylpentadecanoic acid	Biochemical Assay Reagents
14-Methylpentadecanoic acid is a branched-chain fatty acid that has been found in soil bacteria. 1,2

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W015874

2-Hydroxy-2-methylbutanoic acid	Structural Classification Other disease Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Hydroxy-2-methylbutanoic acid is a branched-chain fatty acid. 2-Hydroxy-2-methylbutanoic acid accumulates at high levels in the culture supernatants of colorectal cancer-associated bacteria. 2-Hydroxy-2-methylbutanoic acid is also present in the urine of patients with 2-hydroxyglutaric aciduria and maple syrup urine disease .

HY-W010516

2-Methylvaleric acid 2-Methylpentanoic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-131503

13-Methyltetradecanoic acid 13-MTD; 13-Methylmyristic acid	Classification of Application Fields Leguminosae Glycine max (L.) merr Ketones, Aldehydes, Acids Plants Disease Research Fields Cancer Source Classification	Apoptosis
13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

HY-155157

PF-07247685	Cardiovascular Disease Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07247685 is a BCKDC kinase (BDK) inhibitor (EC₅₀=2.2 nM). PF-07247685 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07247685 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-155156

PF-07238025	Cardiovascular Disease Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
PF-07238025 is a BCKDC kinase (BDK) inhibitor (EC₅₀=19 nM). PF-07238025 stabilizes the interaction between BDK and BCKDH core subunit E2 and prevents phosphorylation of E1. While BDK mediates branched-chain ketoacid dehydrogenase (BCKDH) phosphorylation, and inhibition of BCKDH is involved in controlling the rate-limiting step of branched-chain amino acid (BCAA) degradation. Impaired BCAA catabolism has been associated with several diseases, particularly cardiometabolic diseases, including heart failure (HF), type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and obesity. PF-07238025 improved cardiometabolic endpoints and improves glucose tolerance in mice .

HY-W010516R

2-Methylvaleric acid (Standard) 2-Methylpentanoic acid (Standard)	Structural Classification other families Ketones, Aldehydes, Acids Plants Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].

HY-W143057

2-Methylhexadecanoic acid	Structural Classification Natural Products other families Coniogramme japonica (Thunb.) Diels Plants Source Classification	Biochemical Assay Reagents
2-Methylhexadecanoic acid is a C17 branched-chain fatty acid and can be used as a branched fatty acid feedstock for transesterification .

Cat. No.	Product Name	Chemical Structure

HY-131503S

13-Methyltetradecanoic acid-d6
13-Methyltetradecanoic acid-d6 is a deuterated labeled 13-Methyltetradecanoic acid . 13-Methyltetradecanoic acid (13-MTD), a saturated branched-chain fatty acid with potent anticancer effects. 13-Methyltetradecanoic acid induces apoptosis in many types of human cancer cells .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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