α-Methylacyl-CoA racemase 1
α-methylacyl-CoA racemase 1 is an enzyme that catalyzes a key chiral inversion step in the metabolism of branched-chain fatty acids, and used as a maker in prostate and other cancer.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
α-methylacyl-CoA racemase protein levels are increased in all prostate and some other cancer cells and it is used as a marker. The enzyme requires no cofactors and catalyzes its reaction by a stepwise 1,1-proton transfer via an enolate intermediate. The biological role ofα-methylacyl-CoA racemase in cancer is complex, linking lipid metabolism with nuclear receptor (e.g. FXR and PPAR) activity and expression of enzymes such as cyclooxygenase-2 (COX-2)[1]. α-methylacyl-CoA racemase 1 is a valuable tool to confirm the diagnosis of prostate cancer, especially if combined with basal cell markers. Microarray analysis reveals that tumours with prominent AMACR expression included adenocarcinomas of the prostate (72%), hepatocellular carcinomas (77%), papillary renal cell carcinomas (70%), and colorectal adenocarcinomas (71%)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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SMILES
[alfa-Methylacyl-CoA racemase 1]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Lloyd MD, et al. α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S. Prog Lipid Res. 2013 Apr;52(2):220-30. [Content Brief]
[2]. Went PT, et al. Abundant expression of AMACR in many distinct tumour types. Pathology. 2006 Oct;38(5):426-32. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α-Methylacyl-CoA racemase 1 Related Classifications
HY-111487 Related Classifications
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