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cockroaches

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By Targets:	Apoptosis (1) Biochemical Assay Reagents (1) Calcium Channel (2) Cholinesterase (ChE) (2) Cytochrome P450 (2) GABA Receptor (2) Isotope-Labeled Compounds (1) nAChR (1) Parasite (2) Sodium Channel (2)
By Research Areas:	Infection (3) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (7)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1113

Diazinon

Dimpylate
Parasite Infection

Diazinon is a thiophosphoric acid ester, is a nonsystemic organophosphate insecticide, used to control cockroaches, silverfish, ants, and fleas.

Diazinon Dimpylate	Parasite	Infection
Diazinon is a thiophosphoric acid ester, is a nonsystemic organophosphate insecticide, used to control cockroaches, silverfish, ants, and fleas.

HY-B0822

Fipronil
Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-B0822R

Fipronil (Standard)	GABA Receptor Cytochrome P450 Apoptosis	Neurological Disease
Fipronil (Standard) is the analytical standard of Fipronil. This product is intended for research and analytical applications. Fipronil is a broad-spectrum insecticide effective against Lepidoptera species as well as thrips, locusts, ants, cockroaches, fleas and ticks. Fipronil selectively inhibits GABA receptor with IC₅₀s of 30 nM and 1600 nM for cockroach and rat GABA receptors, respectively. Glutamate-gated chloride channels (GluCls), which are present in cockroaches but not in mammals, are sensitive to the blocking effect of Fipronil. Fipronil also induces apoptosis in HepG2 cells and promotes the expression of CYP1A1 and CYP3A4 mRNA in human hepatocytes .

HY-B0841S

Acephate-d3	Isotope-Labeled Compounds Cholinesterase (ChE)	Neurological Disease
Acephate-d₃ is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.

HY-P5162

Dc1a	Sodium Channel	Inflammation/Immunology
Dc1a potently promotes opening of the German cockroach Na_v channel (BgNa_v1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .

HY-145297

Flupyrimin

nAChR Neurological Disease

Flupyrimin acts as an antagonist at the insect nicotinic acetylcholine receptor (nAChR) .

Flupyrimin	nAChR	Neurological Disease
Flupyrimin acts as an antagonist at the insect nicotinic acetylcholine receptor (nAChR) .

HY-N7491

Verticilide	Calcium Channel	Inflammation/Immunology
Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-P5179

Huwentoxin I HWTX-I	Calcium Channel Sodium Channel	Neurological Disease
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively .

HY-B1885

Fenitrothion	Parasite Cholinesterase (ChE)	Infection
Fenitrothion, one of the most widely used organophosphorus pesticides, is a cholinesterase inhibiting insecticide/acaricid. Fenitrothion is widely used, as a broad-spectrum insecticide, on cotton crops, vegetables crops, fruit crops, and field crops especially paddy. Fenitrothion leads to accumulation of nitrophenols .

Cat. No.	Product Name	Target	Research Area

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-P3635

Cockroach Myoactive Peptide II Pea-CAH-II	Peptides	Neurological Disease Metabolic Disease
Cockroach Myoactive Peptide II (Pea-CAH-II) is a cockroach neuropeptide. Cockroach Myoactive Peptide II is a member of the adipokinetic hormone/red pigment concentrating hormone (AKH/RPCH) family. Cockroach Myoactive Peptide II can be used for the research of metabolic functions of insect body .

HY-P3636

Cockroach Myoactive Peptide I Pea-CAH-I	Peptides	Neurological Disease
Cockroach Myoactive Peptide I (Pea-CAH-I) is a cockroach neuropeptide, a member of the adipokinetic hormone/red pigment-concentrating hormone family (AKH/RPCH family) .

HY-P1496

Leucokinin VIII

Leucokinin 8
Peptides Neurological Disease

Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.

Leucokinin VIII Leucokinin 8	Peptides	Neurological Disease
Leucokinin VIII is an diuretic octapeptide isolated form head extracts of the cockroach.

HY-P5162

Dc1a	Sodium Channel	Inflammation/Immunology
Dc1a potently promotes opening of the German cockroach Na_v channel (BgNa_v1). Dc1a is a toxin can be isolated from the desert bush spider Diguetia canities .

HY-N7491

Verticilide	Calcium Channel	Inflammation/Immunology
Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

HY-P5179

Huwentoxin I HWTX-I	Calcium Channel Sodium Channel	Neurological Disease
Huwentoxin I (HWTX-I) is a peptide toxin that inhibits voltage-gated sodium channels and N-type calcium channels. Huwentoxin I inhibits sodium channels in rat hippocampus and cockroach dorsal unpaired median (DUM) neurons with IC₅₀ values of 66.1 and 4.80 nM, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7491

Verticilide	Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Inflammation/Immunology Disease Research Fields	Calcium Channel
Verticilide is a ryanodine-binding inhibitor and inhibits ryanodine binding to ryanodine receptors in the cockroach at an IC₅₀ value of 4.2 ?μM (whereas inhibition against mouse ryanodine receptors was weak (IC₅₀=53.9?μM)) .

Cat. No.	Product Name	Chemical Structure

HY-B0841S

Acephate-d3
Acephate-d₃ is the deuterium labeled Acephate. Acephate is an anticholinesterase insecticide that produces cholinotoxicity. Acephate displays weak inhibition of rat AChE but potently inhibits cockroach AChE.

HY-B0822S1

Fipronil-13C6
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

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cockroaches

Inhibitors & Agonists

Peptides

NaturalProducts

Isotope-Labeled Compounds

Natural
Products