deformylase

By Targets:	Aminopeptidase (1) Antibiotic (1) Apoptosis (1) Bacterial (4) Biochemical Assay Reagents (1) Formyl Peptide Receptor (FPR) (3) Influenza Virus (1) MMP (2) Neurokinin Receptor (1) TNF Receptor (2)
By Research Areas:	Cancer (4) Infection (5) Inflammation/Immunology (5) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Aminopeptidase Bacterial MMP Apoptosis Antibiotic	Infection Cancer
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible *peptide deformylase* (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis** inducer. Actinonin has antiproliferative and antitumor activities .

HY-12480

Lanopepden GSK 1322322	Bacterial	Infection
Lanopepden (GSK 1322322) is a peptide deformylase inhibitor active against Staphylococcus aureus strains with MICs of 1 and 1 mg/L for ATCC 29213 and ATCC 25923 strain, respectively .

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-148372

For-Met-Leu-pNA

Biochemical Assay Reagents Cancer

For-Met-Leu-pNA is an N-formylated peptide substrate that can be used in the deformylase assays .
HY-122097

M7594_0037

Others Cancer

M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .

For-Met-Leu-pNA	Biochemical Assay Reagents	Cancer
For-Met-Leu-pNA is an N-formylated peptide substrate that can be used in the deformylase assays .

M7594_0037	Others	Cancer
M7594_0037 is a potent inhibitor of human peptide deformylase (HsPDF) that has anti-tumor activity .

HY-119728

FR198248	Influenza Virus	Infection
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

HY-P0224

*N-Formyl-Met-Leu-Phe* 5+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

HY-P1744

*N-Formyl-Met-Leu-Phe-Lys* fMLFK	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC₅₀s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 ^7.32G, respectively .

HY-P1591

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-P1591A

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-P5740

Cacaoidin	Bacterial	Infection
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .

Cat. No.	Product Name	Target	Research Area

HY-118694

TAPI-0	TNF Receptor MMP Bacterial	Infection Cancer
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC₅₀ of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing .

HY-P0224

*N-Formyl-Met-Leu-Phe* 5+ Cited Publications fMLP; N-Formyl-MLF	TNF Receptor	Inflammation/Immunology
N-Formyl-Met-Leu-Phe (fMLP; N-Formyl-MLF) is a chemotactic peptide and a specific ligand of N-formyl peptide receptor (FPR). N-Formyl-Met-Leu-Ph is reported to inhibit TNF-alpha secretion.

HY-P1756

N-Formyl-Met-Ala-Ser

Peptides Inflammation/Immunology

N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.

*N-Formyl-Met-Ala-Ser*	Peptides	Inflammation/Immunology
N-Formyl-Met-Ala-Ser is a peptide, binds to formyl peptide receptors on neutrophils.

HY-P1591

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-P1744

*N-Formyl-Met-Leu-Phe-Lys* fMLFK	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Met-Leu-Phe-Lys (fMLFK) is a peptide, acts as a potent and selective agonist of FPR1, with EC₅₀s of 3.5 nM, 6.7 μM and 0.88 μM for FPR1, FPR2 and FPR2-D281 ^7.32G, respectively .

HY-P1591A

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-135108

QWF Peptide	Neurokinin Receptor	Neurological Disease
QWF Peptide (Compound 4a) is a substance P antagonist with an IC₅₀ of 0.09 μM. QWF Peptide antagonizes the SP-induced contraction of isolated guinea pig trachea strips with an IC₅₀ of 4.7 μM .

HY-P5740

Cacaoidin	Bacterial	Infection
Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113952

Actinonin 4 Publications Verification (-)-Actinonin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Aminopeptidase Bacterial MMP Apoptosis Antibiotic
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible *peptide deformylase* (PDF) inhibitor with a K_i of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with K_i values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis** inducer. Actinonin has antiproliferative and antitumor activities .

HY-119728

FR198248	Structural Classification Microorganisms Source classification Phenols Polyphenols	Influenza Virus
FR198248 is an anti-influenza agent and peptide deformylase (PDF) inhibitor. FR198248 can be isolated from Aspergillus flavipes. FR198248 potently inhibits the PDF of Staphylococcus aureus with an IC₅₀ of 3.6 µM. FR198248 can be used for antiviral and antibacterial research .

Cat. No.	Compare	Product Name	Species	Source

HY-P71767

	*Peptide deformylase* Protein, S. aureus (P.pastoris, His)** def; def1; pdf1Peptide deformylase; PDF; Polypeptide deformylase	Staphylococcus aureus	P. pastoris
	Peptide deformylase, a crucial enzyme in protein biosynthesis, catalyzes the removal of the formyl group from the N-terminal methionine of newly synthesized proteins. Displaying broad specificity at positions beyond the N-terminal L-methionine, the enzyme ensures proper maturation and functionality of proteins, emphasizing its essential contribution to the intricate process of protein synthesis and modification. Peptide deformylase Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Peptide deformylase protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Peptide deformylase Protein, S. aureus (P.pastoris, His) is 183 a.a., with molecular weight of ~25 kDa.


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deformylase

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