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human MetAP-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MetAP (3) Aminopeptidase (1) Small Interfering RNA (siRNA) (1) VEGFR (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (1) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Recombinant Proteins

Oligonucleotides

Targets Recommended: MetAP

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS08350

METAP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

METAP2 Human Pre-designed siRNA Set A METAP2 Human Pre-designed siRNA Set A

HY-182419

A-849519	MetAP	Cancer
A-849519 is a reversible methionine aminopeptidase-2 (MetAP-2) inhibitor with an IC₅₀ of 19 nM. A-849519 binds to the active site of the Mn ²⁺ form of human *MetAP-2, where the oxygen atom of one acidic functional group interacts with the manganese ion, and another heteroatom binds to the water molecule above the two manganese ions, thereby functionally inhibiting enzyme activity. A-849519 inhibits the methionine processing activity of MetAP-2* as well as the proliferation of fibrosarcoma cells. A-849519 can be used in studies related to fibrosarcoma .

HY-183876

LAF-153	Aminopeptidase	Others
LAF-153 is a Methionine Aminopeptidase-2 (MetAP-2) inhibitor with human IC₅₀ values of 0.074 μM and 0.16 μM.LAF-153 has a t-butyl group extending into the innermost portion of the *MetAP-2* cleft, a lactam ring coordinated in the enzyme’s shallow surface pocket, and three hydroxyl groups coordinating to the two cobalt ions in the enzyme’s active site .

HY-133806

Fumarranol	MetAP VEGFR	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Fumarranol, a Fumagillin (HY-B0751) analogue, is a selective type 2 methionine aminopeptidase (MetAP2) inhibitor with a human IC₅₀ of 3.2 μM. Fumarranol inhibits proliferation of bovine aortic endothelial cells and inhibits angiogenesis in a mouse matrigel plug model. Fumarranol can be used for the researches of cancer, diabetic retinopathy, age-related macular degeneration .

HY-184384

MetAP-2 modulator-1		Neurological Disease Cancer
MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma .

HY-182482

SB-587094	MetAP	Cancer
SB-587094 is a MetAP-2 inhibitor. SB-587094 inhibits cobalt- and manganese-containing hMetAP2. SB-587094 inhibits endothelial cell proliferation. SB-587094 is applicable to cancer-related research .

Species:	Human (2)
Tag:	His (2)
Source:	Sf9 insect cells (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P70364

	METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, His) rHuMethionine aminopeptidase 2/MetAP2, His; Methionine aminopeptidase 2; MAP 2; MetAP 2; p67; p67eIF2; Peptidase M; MetAP2; MAP2	Human	Sf9 insect cells
	METAP2/Methionine aminopeptidase 2 protein removes N-terminal methionine from nascent proteins. It preferentially cleaves when the second residue is small and uncharged. METAP2 has higher catalytic activity for Met-Val peptides than METAP1, suggesting its role in processing Met-Val and Met-Thr sequences in vivo. It also protects EIF2S1 from phosphorylation by inhibitory kinases, regulating protein synthesis. METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by sf9 insect cells , with N-6*His labeled tag.

HY-P703925

	METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, C-His) MAP2 Protein, human; MNPEP Protein, human; p67 Protein, human; p67eIF2 Protein, human	Human	Sf9 insect cells
	METAP2/Methionine aminopeptidase 2 Protein, Human (sf9, C-His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells, with C-His tag.

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METAP2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
METAP2 Human Pre-designed siRNA Set A contains three designed siRNAs for METAP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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