2. Disease Areas
  3. Cancer Neurological, Eye or Ear Disease
  4. Neuroblastoma CNS Neoplasm
  5. MetAP-2 modulator-1

MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma.

For research use only. We do not sell to patients.

MetAP-2 modulator-1

MetAP-2 modulator-1 Chemical Structure

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MetAP-2 modulator-1 Related Antibodies

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Description

MetAP-2 modulator-1 is a MetAP-2 modulator. MetAP-2 modulator-1 reduces the MetAP-2 enzyme level in cells. MetAP-2 modulator-1 exhibits anticancer effects against neuroblastoma. MetAP-2 modulator-1 can be used in studies related to neuroblastoma[1].

In Vitro

MetAP-2 modulator-1 (Compound 4e) (2.5 μg/mL; 24 h) significantly reduces MetAP-2 enzyme levels in human neuroblastoma SH-SY5Y cells, resulting in a measured level of 8.8 ng/μg protein after 24 h exposure at 2.5 μg/mL[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MetAP-2 modulator-1 Related Antibodies

ELISA Assay[1]

Cell Line: human neuroblastoma SH-SY5Y cells
Concentration: 2.5 μg/mL
Incubation Time: 24 h
Result: Reduced MetAP-2 level to 8.8 ng/μg protein, which was a significant decrease compared to unexposed control cells (56.4 ng/μg protein) and positive control fumagillin (85.9 ng/μg protein).
Molecular Weight

394.42

Formula

C20H15FN4O2S
SMILES

OC1=CC=C(C=C1)/C=N/NC(CC2=CSC3=NC(C4=CC=C(C=C4)F)=CN23)=O
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Purity & Documentation
References
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MetAP-2 modulator-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MetAP-2 modulator-1MetAP-2neuroblastoma cellsHis231Asp442Methionine aminopeptidase-2human neuroblastoma SH-SY5Y cellsCo2+human MetAP-2Inhibitorinhibitorinhibit

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