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Pathways Recommended:	Protein Tyrosine Kinase/RTK

Results for "

low-molecular-weight protein tyrosine phosphatase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphatase (8)
By Research Areas:	Cancer (1) Metabolic Disease (7)

Targets Recommended: Phosphatase Btk Syk SHP2 PhosTACs PTEN Pyk2 TNK1 Tyrosine Hydroxylase DYRK BRK FAK SHP1 FLT3 Anaplastic lymphoma kinase (ALK)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111489B

LMPTP inhibitor 1 dihydrochloride	Phosphatase	Metabolic Disease
LMPTP INHIBITOR 1 (dihydrochloride) is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC₅₀ of 0.8 μM LMPTP-A.

HY-151591

SPAA-52	Phosphatase	Metabolic Disease
SPAA-52 is an orally active, competitive and reversible **low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC₅₀=4 nM, K_i**=1.2 nM). SPAA-52 can be used in diabete research .

HY-111489A

LMPTP inhibitor 1 hydrochloride	Phosphatase	Metabolic Disease
LMPTP inhibitor 1 hydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC₅₀ of 0.8 μM LMPTP-A.

HY-111489

LMPTP inhibitor 1	Phosphatase	Metabolic Disease
LMPTP inhibitor 1 is a selective inhibitor of low molecular weight protein tyrosine phosphatase (LMPTP), with an IC₅₀ of 0.8 μM LMPTP-A.

HY-135564B

(Rac)-RK-682	Phosphatase	Cancer
(Rac)-RK-682, a racemate of RK-682, is a protein tyrosine phosphatases (PTPases) inhibitor. (Rac)-RK-682 inhibits protein tyrosine phosphatase 1B (PTP-1B), low molecular weight protein tyrosine phosphatases (LMW-PTP), and cell division cycle 25B (CDC-25B) with IC₅₀s of 8.6 μM, 12.4 μM, and 0.7 μM, respectively .

HY-151591A

SPAA-52 ammonium	Phosphatase	Metabolic Disease
SPAA-52 (ammonium) is a low molecular weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC₅₀ = 4 nM; IC₅₀ = 1.2 nM). SPAA-52 (ammonium) can be used in the research of diabetes mellitus .

HY-124420

MLS-0322825	Phosphatase	Metabolic Disease
MLS-0322825 is a selective low molecular weight protein tyrosine phosphatase (LMPTP) inhibitor with an IC₅₀ of 3.3 μM for LMPTP-A. MLS-0322825 shows exquisite selectivity over other phosphatases (class I tyrosine-specific lymphoid phosphatase (LYP) and class I dual-specific vaccinia H1-related phosphatase (VHR)). MLS-0322825 can be used for the research of type 2 diabetes ^[1].

HY-182536

LMPTP IN-2	Phosphatase	Metabolic Disease
LMPTP IN-2 is a selective protein tyrosine phosphatase (LMPTP) inhibitor with an IC₅₀ of 0.020 μM. LMPTP IN-2 exerts inhibitory effects through a non-competitive mechanism. LMPTP IN-2 can be used for research on obesity-related insulin resistance and type 2 diabetes .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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low-molecular-weight protein tyrosine phosphatase

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