2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. SPAA-52

SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research.

For research use only. We do not sell to patients.

SPAA-52 Chemical Structure

SPAA-52 Chemical Structure

CAS No. : 2837000-75-4

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Solid + Solvent
10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

SPAA-52 Related Antibodies

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Description

SPAA-52 is an orally active, competitive and reversible low-molecular-weight protein tyrosine phosphatase (LMW-PTP) inhibitor (IC50=4 nM, Ki=1.2 nM). SPAA-52 can be used in diabete research[1].

IC50 & Target

IC50: 4 nM (LMW-PTP)[1]
In Vivo

1.19 Plasma PK Parameters in Healthy Mice[1]

Compound SPAA-52
dose route 2 mg/kg IV 10 mg/kg PO
AUC (0−8 h) (nM h) 15,100 37,300
C0 or Cmax (nM) 13,400 9690
C0 or Cmax unbound (nM) 332 233
Vdss (L/kg) 0.42
CL (mL/min/kg) 5.65
T1/2 (h) 1.41 4.2
F (%) 34
1.19 Plasma PK Parameters in Healthy Rats[1]
Compound SPAA-52
dose route 3 mg/kg PO
AUC (0-12 h) (nM h) 4660
Cmax (nM) 877
Cmax unbound (nM) 21
Vdss (L/kg) 0.42
Tmax (h) 2.0
T1/2 (h) 2.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

388.03

Formula

C8H8Br2N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(O)(NC(NC1=CC(Br)=C(C)C(Br)=C1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (257.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5771 mL 12.8856 mL 25.7712 mL
5 mM 0.5154 mL 2.5771 mL 5.1542 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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V1

=
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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5771 mL 12.8856 mL 25.7712 mL 64.4280 mL
5 mM 0.5154 mL 2.5771 mL 5.1542 mL 12.8856 mL
10 mM 0.2577 mL 1.2886 mL 2.5771 mL 6.4428 mL
15 mM 0.1718 mL 0.8590 mL 1.7181 mL 4.2952 mL
20 mM 0.1289 mL 0.6443 mL 1.2886 mL 3.2214 mL
25 mM 0.1031 mL 0.5154 mL 1.0308 mL 2.5771 mL
30 mM 0.0859 mL 0.4295 mL 0.8590 mL 2.1476 mL
40 mM 0.0644 mL 0.3221 mL 0.6443 mL 1.6107 mL
50 mM 0.0515 mL 0.2577 mL 0.5154 mL 1.2886 mL
60 mM 0.0430 mL 0.2148 mL 0.4295 mL 1.0738 mL
80 mM 0.0322 mL 0.1611 mL 0.3221 mL 0.8054 mL
100 mM 0.0258 mL 0.1289 mL 0.2577 mL 0.6443 mL
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SPAA-52 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPAA-522837000-75-4SPAA52SPAA 52Phosphataseoral activitycompetitivereversiblediabeteInhibitorinhibitorinhibit

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