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Results for "

periodontitis model

" in MedChemExpress (MCE) Product Catalog:

8

Inhibitors & Agonists

2

Biochemical Assay Reagents

3

Peptides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1717
    AMY-101
    Maximum Cited Publications
    7 Publications Verification

    Cp40

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 (Cp40), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101
  • HY-P1717B
    AMY-101 acetate
    Maximum Cited Publications
    7 Publications Verification

    Cp40 acetate

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 acetate (Cp40 acetate), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 acetate (Cp40 acetate) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101 acetate
  • HY-P1717A
    AMY-101 TFA
    Maximum Cited Publications
    7 Publications Verification

    Cp40 TFA

    		 Complement System SARS-CoV Inflammation/Immunology
    AMY-101 TFA (Cp40 TFA), a peptidic inhibitor of the central complement component C3 (KD = 0.5 nM), inhibits naturally occurring periodontitis in non-human primates (NHPs). AMY-101 (Cp40) exhibits a favorable anti-inflammatory activity in models with COVID-19 severe pneumonia with systemic hyper inflammation .
    AMY-101 TFA
  • HY-W004761
    Tetrahydroxydiboron

    Hypodiboric acid

    		 Biochemical Assay Reagents Reactive Oxygen Species (ROS) Infection
    Tetrahydroxydiboron acts as a hydrogel initiator and bioadhesion promoter, with broad-spectrum antibacterial activity, ROS scavenging capacity and osteogenic induction properties. Tetrahydroxydiboron initiates rapid gelation by generating free radicals through reactions with vinyl monomers and dissolved oxygen, and overcomes oxygen inhibition without deoxygenation or external triggers. Tetrahydroxydiboron achieves strong bioadhesion through interaction with carboxymethyl chitosan. Tetrahydroxydiboron can be used in the research of periodontitis and related inflammatory diseases .
    Tetrahydroxydiboron
  • HY-W002879
    4-Hydroxyphenylboronic acid pinacol ester

    		Reactive Oxygen Species (ROS) Inflammation/Immunology
    4-Hydroxyphenylboronic acid pinacol ester is a ROS-responsive component. 4-Hydroxyphenylboronic acid pinacol ester can structurally modify hyaluronic acid to prepare ROS-responsive intelligent nanocarriers and compound delivery systems. 4-Hydroxyphenylboronic acid pinacol ester endows hyaluronic acid-based nanocarriers with ROS responsiveness, enabling them to rapidly release the encapsulated Curcumin (HY-N0005) in the presence of reactive oxygen species. 4-Hydroxyphenylboronic acid pinacol ester is applicable to research related to periodontitis. 4-Hydroxyphenylboronic acid pinacol ester can also be used for the synthesis of boronic acid-modified resins .
    4-Hydroxyphenylboronic acid pinacol ester
  • HY-129991
    JNJ-17166864

    		CCR Inflammation/Immunology
    JNJ-17166864 is a highly selective CCR2 antagonist. JNJ-17166864 has low oral bioavailability. JNJ-17166864 can significantly reduce the area of alveolar bone loss in a mouse model of periodontitis induced by Porphyromonas gingivalis infection. JNJ-17166864 can be used in the research of inflammatory diseases such as allergic rhinitis and periodontitis .
    JNJ-17166864
  • HY-162280
    PROTAC BTK Degrader-9

    		PROTACs RANKL/RANK Nuclear Factor of activated T Cells (NFAT) Btk Cancer
    PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCγ2-Ca 2+-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model .
    PROTAC BTK Degrader-9
  • HY-138454
    MEG hemisulfate

    Mercaptoethylguanidine hemisulfate

    		 NO Synthase Inflammation/Immunology
    MEG (Mercaptoethylguanidine) hemisulfate is a potent and selective inhibitor of the inducible NO synthase (iNOS), with EC50s of 11.5, 110, and 60 μM for iNOS, ecNOS, and bNOS respectively in tissue homogenates. MEG hemisulfate is also a potent scavenger of peroxynitrite and inhibits peroxynitrite-induced oxidative processes. MEG hemisulfate has a protective effect in many experimental models of inflammation, including ischemia/reperfusion injury, periodontitis, hemorrhagic shock, inflammatory bowel disease, and endotoxic and septic shock .
    MEG hemisulfate

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